Human Anatomy
6th Edition
ISBN: 9781260399820
Author: SALADIN, Kenneth
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 15, Problem 15.3.17AYLO
Summary Introduction
To write:
The position and interaction of the language centers of the cerebrum.
Introduction:
The cerebral cortex is the convoluted surface layer of the cerebrum gray matter. It functions mainly in the coordination of sensory and motor information. It is formed of tightly packed neurons is wrinkly in structure.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 15 Solutions
Human Anatomy
Ch. 15.1 - Prob. 1AWYKCh. 15.1 - List the three major parts of the brain and...Ch. 15.1 - Define gyrus and suicus.Ch. 15.1 - Prob. 3BYGOCh. 15.1 - Prob. 4BYGOCh. 15.1 - Prob. 5BYGOCh. 15.1 - Prob. 6BYGOCh. 15.1 - Name the two components of the brain barrier...Ch. 15.2 - Prob. 8BYGOCh. 15.2 - Prob. 9BYGO
Ch. 15.2 - Prob. 10BYGOCh. 15.2 - Describe the reticular formation and list several...Ch. 15.2 - Describe the general functions of the cerebellum.Ch. 15.3 - Prob. 1AWYKCh. 15.3 - Prob. 13BYGOCh. 15.3 - List at least six functions of the hypothalamus.Ch. 15.3 - Prob. 15BYGOCh. 15.3 - Prob. 16BYGOCh. 15.3 - Prob. 17BYGOCh. 15.3 - Prob. 18BYGOCh. 15.3 - Prob. 19BYGOCh. 15.3 - Prob. 20BYGOCh. 15.4 - Prob. 21BYGOCh. 15.4 - Prob. 22BYGOCh. 15.4 - If the oculomotor, trochlear, or abducens nerve...Ch. 15.4 - Prob. 24BYGOCh. 15.4 - Prob. 25BYGOCh. 15.5 - Prob. 26BYGOCh. 15.5 - Prob. 27BYGOCh. 15.5 - Describe the neuroanatomical and behavioral...Ch. 15 - Prob. 15.1.1AYLOCh. 15 - The meanings of rostral and caudal in CNS anatomyCh. 15 - Prob. 15.1.3AYLOCh. 15 - Prob. 15.1.4AYLOCh. 15 - Prob. 15.1.5AYLOCh. 15 - The meninges of the brain; how they differ from...Ch. 15 - Prob. 15.1.7AYLOCh. 15 - Prob. 15.1.8AYLOCh. 15 - Prob. 15.1.9AYLOCh. 15 - The location, anatomical features, and functions...Ch. 15 - Prob. 15.2.2AYLOCh. 15 - Prob. 15.2.3AYLOCh. 15 - Prob. 15.3.1AYLOCh. 15 - Prob. 15.3.2AYLOCh. 15 - Prob. 15.3.3AYLOCh. 15 - Prob. 15.3.4AYLOCh. 15 - Prob. 15.3.5AYLOCh. 15 - Prob. 15.3.6AYLOCh. 15 - Prob. 15.3.7AYLOCh. 15 - Prob. 15.3.8AYLOCh. 15 - The location, major components, and general...Ch. 15 - Prob. 15.3.10AYLOCh. 15 - Prob. 15.3.11AYLOCh. 15 - Prob. 15.3.12AYLOCh. 15 - Prob. 15.3.13AYLOCh. 15 - Prob. 15.3.14AYLOCh. 15 - Prob. 15.3.15AYLOCh. 15 - The motor functions of the basal nuclei and...Ch. 15 - Prob. 15.3.17AYLOCh. 15 - Prob. 15.3.18AYLOCh. 15 - The roles of the hypothalamus, amygdala, and...Ch. 15 - Prob. 15.3.20AYLOCh. 15 - Prob. 15.3.21AYLOCh. 15 - Prob. 15.3.22AYLOCh. 15 - Prob. 15.4.1AYLOCh. 15 - Prob. 15.4.2AYLOCh. 15 - The common effects of aging on the central nervous...Ch. 15 - Prob. 15.5.2AYLOCh. 15 - Prob. 15.5.3AYLOCh. 15 - Prob. 1TYRCh. 15 - Hearing is associated mainly with the limbic...Ch. 15 - Prob. 3TYRCh. 15 - Prob. 4TYRCh. 15 - Prob. 5TYRCh. 15 - Prob. 6TYRCh. 15 - Because of a brain lesion, a certain patient never...Ch. 15 - Prob. 8TYRCh. 15 - Prob. 9TYRCh. 15 - Prob. 10TYRCh. 15 - Prob. 11TYRCh. 15 - Prob. 12TYRCh. 15 - Prob. 13TYRCh. 15 - Prob. 14TYRCh. 15 - Prob. 15TYRCh. 15 - Prob. 16TYRCh. 15 - Your personality is determined mainly by which...Ch. 15 - Prob. 18TYRCh. 15 - Linear, analytical, and verbal thinking occurs in...Ch. 15 - Prob. 20TYRCh. 15 - Prob. 1BYMVCh. 15 - Prob. 2BYMVCh. 15 - State a meaning of each word element and give a...Ch. 15 - State a meaning of each word element and give a...Ch. 15 - Prob. 5BYMVCh. 15 - State a meaning of each word element and give a...Ch. 15 - Prob. 7BYMVCh. 15 - Prob. 8BYMVCh. 15 - Prob. 9BYMVCh. 15 - Prob. 10BYMVCh. 15 - Prob. 1WWWTSCh. 15 - Prob. 2WWWTSCh. 15 - Prob. 3WWWTSCh. 15 - Prob. 4WWWTSCh. 15 - Prob. 5WWWTSCh. 15 - Prob. 6WWWTSCh. 15 - Briefly explain why each of the following...Ch. 15 - Prob. 8WWWTSCh. 15 - Prob. 9WWWTSCh. 15 - Prob. 10WWWTSCh. 15 - Prob. 1TYCCh. 15 - Prob. 2TYCCh. 15 - Prob. 3TYCCh. 15 - Prob. 4TYCCh. 15 - Prob. 5TYC
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