Human Anatomy
6th Edition
ISBN: 9781260399820
Author: SALADIN, Kenneth
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 15, Problem 15.1.9AYLO
Summary Introduction
To write:
The constituents, significance, limitations of the brain barrier system.
Introduction:
The nervous system of a human is divided into two subdivisions: the central nervous system or CNS (includes the spinal cord and the brain) and the peripheral nervous system or PNS (includes rest all parts of the nervous system except spinal cord and brain).
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 15 Solutions
Human Anatomy
Ch. 15.1 - Prob. 1AWYKCh. 15.1 - List the three major parts of the brain and...Ch. 15.1 - Define gyrus and suicus.Ch. 15.1 - Prob. 3BYGOCh. 15.1 - Prob. 4BYGOCh. 15.1 - Prob. 5BYGOCh. 15.1 - Prob. 6BYGOCh. 15.1 - Name the two components of the brain barrier...Ch. 15.2 - Prob. 8BYGOCh. 15.2 - Prob. 9BYGO
Ch. 15.2 - Prob. 10BYGOCh. 15.2 - Describe the reticular formation and list several...Ch. 15.2 - Describe the general functions of the cerebellum.Ch. 15.3 - Prob. 1AWYKCh. 15.3 - Prob. 13BYGOCh. 15.3 - List at least six functions of the hypothalamus.Ch. 15.3 - Prob. 15BYGOCh. 15.3 - Prob. 16BYGOCh. 15.3 - Prob. 17BYGOCh. 15.3 - Prob. 18BYGOCh. 15.3 - Prob. 19BYGOCh. 15.3 - Prob. 20BYGOCh. 15.4 - Prob. 21BYGOCh. 15.4 - Prob. 22BYGOCh. 15.4 - If the oculomotor, trochlear, or abducens nerve...Ch. 15.4 - Prob. 24BYGOCh. 15.4 - Prob. 25BYGOCh. 15.5 - Prob. 26BYGOCh. 15.5 - Prob. 27BYGOCh. 15.5 - Describe the neuroanatomical and behavioral...Ch. 15 - Prob. 15.1.1AYLOCh. 15 - The meanings of rostral and caudal in CNS anatomyCh. 15 - Prob. 15.1.3AYLOCh. 15 - Prob. 15.1.4AYLOCh. 15 - Prob. 15.1.5AYLOCh. 15 - The meninges of the brain; how they differ from...Ch. 15 - Prob. 15.1.7AYLOCh. 15 - Prob. 15.1.8AYLOCh. 15 - Prob. 15.1.9AYLOCh. 15 - The location, anatomical features, and functions...Ch. 15 - Prob. 15.2.2AYLOCh. 15 - Prob. 15.2.3AYLOCh. 15 - Prob. 15.3.1AYLOCh. 15 - Prob. 15.3.2AYLOCh. 15 - Prob. 15.3.3AYLOCh. 15 - Prob. 15.3.4AYLOCh. 15 - Prob. 15.3.5AYLOCh. 15 - Prob. 15.3.6AYLOCh. 15 - Prob. 15.3.7AYLOCh. 15 - Prob. 15.3.8AYLOCh. 15 - The location, major components, and general...Ch. 15 - Prob. 15.3.10AYLOCh. 15 - Prob. 15.3.11AYLOCh. 15 - Prob. 15.3.12AYLOCh. 15 - Prob. 15.3.13AYLOCh. 15 - Prob. 15.3.14AYLOCh. 15 - Prob. 15.3.15AYLOCh. 15 - The motor functions of the basal nuclei and...Ch. 15 - Prob. 15.3.17AYLOCh. 15 - Prob. 15.3.18AYLOCh. 15 - The roles of the hypothalamus, amygdala, and...Ch. 15 - Prob. 15.3.20AYLOCh. 15 - Prob. 15.3.21AYLOCh. 15 - Prob. 15.3.22AYLOCh. 15 - Prob. 15.4.1AYLOCh. 15 - Prob. 15.4.2AYLOCh. 15 - The common effects of aging on the central nervous...Ch. 15 - Prob. 15.5.2AYLOCh. 15 - Prob. 15.5.3AYLOCh. 15 - Prob. 1TYRCh. 15 - Hearing is associated mainly with the limbic...Ch. 15 - Prob. 3TYRCh. 15 - Prob. 4TYRCh. 15 - Prob. 5TYRCh. 15 - Prob. 6TYRCh. 15 - Because of a brain lesion, a certain patient never...Ch. 15 - Prob. 8TYRCh. 15 - Prob. 9TYRCh. 15 - Prob. 10TYRCh. 15 - Prob. 11TYRCh. 15 - Prob. 12TYRCh. 15 - Prob. 13TYRCh. 15 - Prob. 14TYRCh. 15 - Prob. 15TYRCh. 15 - Prob. 16TYRCh. 15 - Your personality is determined mainly by which...Ch. 15 - Prob. 18TYRCh. 15 - Linear, analytical, and verbal thinking occurs in...Ch. 15 - Prob. 20TYRCh. 15 - Prob. 1BYMVCh. 15 - Prob. 2BYMVCh. 15 - State a meaning of each word element and give a...Ch. 15 - State a meaning of each word element and give a...Ch. 15 - Prob. 5BYMVCh. 15 - State a meaning of each word element and give a...Ch. 15 - Prob. 7BYMVCh. 15 - Prob. 8BYMVCh. 15 - Prob. 9BYMVCh. 15 - Prob. 10BYMVCh. 15 - Prob. 1WWWTSCh. 15 - Prob. 2WWWTSCh. 15 - Prob. 3WWWTSCh. 15 - Prob. 4WWWTSCh. 15 - Prob. 5WWWTSCh. 15 - Prob. 6WWWTSCh. 15 - Briefly explain why each of the following...Ch. 15 - Prob. 8WWWTSCh. 15 - Prob. 9WWWTSCh. 15 - Prob. 10WWWTSCh. 15 - Prob. 1TYCCh. 15 - Prob. 2TYCCh. 15 - Prob. 3TYCCh. 15 - Prob. 4TYCCh. 15 - Prob. 5TYC
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