Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 15, Problem 14QP
Summary Introduction
To determine: The methods to determine the function of a gene that has been cloned.
Introduction: For the study of a genetic disorder, scientists must know the location of the gene and the normal function of the protein encoded by this gene. The other essential point is to know about the mutant gene or protein that produces the disease
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It has been suggested that it would make the study of human diseases easier if cloned transgenic animals
were produced that carried faulty versions of human genes (e.g., the gene that causes cystic fibrosis).
a. Why would such animals be useful in medical research? :
b. What ethical questions are raised by the creation of such transgenic animals?
In the 1996 movie Multiplicity, Doug (Michael Keaton) is a construction worker who wants to spend more time with his family. He meets a friendly scientist (aren't we all?) who has a method for cloning humans. Doug decides to make a clone of himself who can do his work while he spends time with his family. The clone, named "Two", seems great at first, but later develops some functional problems. Two gets tired of working and clones himself to make "Three" to take over. Three then leads to "Four". Each successive clone seems to have an increasing number of issues in function. Ignoring ethical and technical considerations with making adult clones of a human, is there any logical or genetic validity to the premise that make a clone might create problems? If so, what might some of those problems be?
Let’s say, you want to deliver a gene into a cell and in your lab, there are lot of options available to do that. Describe five different options that you can use to deliver that gene.
Chapter 15 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - The gene controlling ABO blood type and the gene...Ch. 15 - Hemophilia and color blindness are both recessive...Ch. 15 - Prob. 3QPCh. 15 - Prob. 4QP
Ch. 15 - How many nucleotides does the human genome...Ch. 15 - Which of the following best describes the process...Ch. 15 - Which of the following is NOT an activity carried...Ch. 15 - Prob. 8QPCh. 15 - Prob. 9QPCh. 15 - What percentage of the DNA in the genome actually...Ch. 15 - When the human genome sequence was finally...Ch. 15 - One unexpected result of the sequencing of the...Ch. 15 - Prob. 13QPCh. 15 - Prob. 14QPCh. 15 - Prob. 15QPCh. 15 - Prob. 16QPCh. 15 - Prob. 17QP
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- In the 1996 movie Multiplicity, Doug (played by Michael Keaton) is a construction worker who wants to spend more time with his family. He meets a friendly scientist who has developed a method for cloning humans. Doug decides to make a clone of himself who can take over his work while he spends quality time with his family. The clone, named “Two,” seems great at first, but later problems surface in his functioning. Two decides to make a clone of himself, so he won’t have to work, and creates Three. A fourth clone is eventually made. Each successive clone seems to have more problems. Ignore, for the present, the technical difficulties and ethical problems with making an instantaneous adult clone of a human. Is there any genetic validity to the premise that making a clone of a clone might create problems? If so, what might those problems be?arrow_forwardGive a schematic diagram of how we can Treatment Down's syndrome by using gene therapy? Please answer at your own words,please..arrow_forwardI believe that there are many good things that can come out of people getting to design their baby’s genetic material. But there are also many bad things as well. From the article by Bio medical about the pros and cons of having a designer baby it states that a pro is that this type of engineering can “ might help prevent genetic diseases such as Alzheimer’s, Huntington’s Disease, down syndrome, Spinal Muscular Atrophy, and many others”. I think that it is great that we could get rid of Alzheimer’s due to how destructive it can be to the people that suffer it. But I think the other diseases that it can eliminate is horrible due to them making our world a more unique place such as people with autism, Down syndrome. By doing this it could eliminate the whole population of people with disabilities community and make everyone “normal”. Another bad that I found in the article Ethics of designer babies which states that a major flaw for these babies is “designer baby technologies suggest…arrow_forward
- Give a schematic diagram of how we can Treatment Down Syndrome by using gene therapy? Please answer at your own words,please..arrow_forwardpick a specific disease that is currently a candidate for gene therapy—(a)briefly describing the gene mutation(s) and resulting disease symptoms, (b)brief description of a current gene therapy approach(es) for this disease. Has this approach shown any potential successes in disease treatment?arrow_forwardIn a clinical context, doctors are evaluating a therapy for a new patient (say patient B) that they have reasons to believe might develop a cancer similar to another patient they treated successfully (patient A). They know that the severity of the cancer is mainly associated with mutations in a specific gene (BRCAI). Suggest a technique that can be used to rapidly assess the similarity between the genetic panerns of patients A and B, without the need to sequence the entire gene, and briefly describe it. A team of scientists are interested in the amplification of a specific DNA fragment in a large plasmid of about 10000 bps. (0) (11) The sequence the scientists are interested in is 5'-CATTGATTATTG[...JATCAATTACGGG-3" 3-GTAACTAATAAG[...]TAGTTAATGCCC-5* Where [...] indicates a longer 100bps sequence. Provide two possible primers that the scientists should use to address their need, if they want to be sure they specifically address this region in the entire plasmid. Briefly explain the…arrow_forward
- Because genetic engineering involves the modification of an organism's set of instructions, it has created a dilemma raising both moral and ethical concerns. For instance, a biotechnological company has found a way to produce rice that is immune to pests and diseases, which is vital for the establishment of food security. However, the methods that will be implemented are by splicing off the genes of endangered pandas using invasive procedures that may harm their population. Will you support this? Why or why not? Limit your answers to 5 sentences or less. Be brief and concise.arrow_forwardAlthough it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?arrow_forwardYou just graduated from college and started working at a biotech startup called Scrofabulous. Your first job assignment is to clone the pig gene for the hormone prolactin. Assume that the pig gene for prolactin has not yet been isolated, sequenced, or mapped; What would be the most useful and economical first step to go about identifying and cloning the pig gene for prolactin? use the amino acid sequence of mouse prolactin to design a pair of degenerate oligonucleotide PCR primers to PCR-amplify the pig prolactin gene. RNAseq the pituitary gland of the pig, the most abundant gene is likely to to be prolactin Conduct a proteome search for peptides that match parts of mouse prolactin protein Sequence the pig genome, then translate the genome to find the gene predicted to encode for prolactin Crystalize the mouse prolactin protein and use Google's DeepMind Al to find the closest amino acid sequence in the pig proteomearrow_forward
- Forward Genetics Analysis uses a variety of beneficial approaches to identify never before described genes. For each of the following approaches or outcomes, briefly (maximum 2 sentences) discuss in your own words, their purpose in Forward Genetics Analysis. c) Mendelian ratios d) Genetic screenarrow_forwardYou are working in the lab with two known carcinogens found in cigarette smoke: Benzo(a)pyren (BaP) and nitrosamine ketone (NNK). BaP is an aromatic hydrocarbon and the mechanism of carcinogenesis is through oxidation reactions with DNA. NNK is a nitrosoamine. Describe how these two kinds of carcinogens lead to mutations. (Be detailed. Remember you are graded on effort/completeness.)arrow_forwardhttps://www.khanacademy.org/science/biology/biotech-dna-technology/dna-cloning-tutorial/a/overview-dna-cloning That is the link for the example ^arrow_forward
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