EBK BIOLOGY
4th Edition
ISBN: 8220102797376
Author: BROOKER
Publisher: YUZU
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Chapter 14.4, Problem 4CC
Summary Introduction
To describe: The chances of occurrence of cancer if both copies of the Rb gene and both the copies of the E2F gene become inactive due to mutations.
Introduction: The malfunctioning in the process of cell differentiation causes the accumulation of cells at a specific place of the body. The accumulation of cells results in the condition of cancer. There are various mutagens present in the environmental conditions that influence the working pathway of the process of the cell cycle.
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FBBS 2 Worksheet 2
Name
HINT: when you are explaining mechanisms affected by mutations, think about molecular interactions, or
enzymatic functions, or conformational changes that are involved in the normal pathways, since these are the
aspects most likely to be affected by mutations or drugs, or viral proteins.
If a consequence of a mutation/drug/virus results in a cdk being more frequently active, then the cell cycle will
proceed at the given checkpoint. If the consequence of a mutation/drug/virus results in a cdk being
inactivated or inhibited, then the cell cycle is stopped at the given checkpoint.
cdc2
kinase
Inactive
1) Given the following diagram of a mechanism regulating the cell cycle of the fission yeast S. pombe.
Interphase (G₂)
CAK
Wee1
Cyclin
Thr161-P Tyr15-P
cdc2
kinase
Cyclin
Inactive
Thr161-P
cdc25
G₂ fission
yeast cell
cdc2
kinase
Cyclin
Active
Interphase (G₁)
Post-mitotic
fission
yeast cells
Date
cdc2
kinase
Dr. Milani
Inactive
Cyclin
Degradation
A) Predict the…
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Chapter 14 Solutions
EBK BIOLOGY
Ch. 14.1 - Consequences of Mutations Concept Check: Based on...Ch. 14.1 - Prob. 2CCCh. 14.1 - Prob. 3CCCh. 14.2 - Prob. 1EQCh. 14.2 - Prob. 2EQCh. 14.2 - Prob. 3EQCh. 14.2 - Prob. 1CCCh. 14.2 - Prob. 2CCCh. 14.3 - DNA Repair Concept Check: Which components of the...Ch. 14.3 - Why is this person so sensitive to sunlight?...
Ch. 14.4 - Prob. 1CCCh. 14.4 - Prob. 1BCCh. 14.4 - Prob. 2CCCh. 14.4 - Prob. 3CCCh. 14.4 - Prob. 4CCCh. 14 - Prob. 1TYCh. 14 - Prob. 2TYCh. 14 - Prob. 3TYCh. 14 - Prob. 4TYCh. 14 - Prob. 5TYCh. 14 - The Ames test a. provides a way to determine if...Ch. 14 - Xeroderma pigmentosum a. is a genetic disorder...Ch. 14 - Prob. 8TYCh. 14 - Prob. 9TYCh. 14 - Prob. 10TYCh. 14 - Prob. 1CQCh. 14 - Prob. 2CQCh. 14 - Prob. 3CQCh. 14 - Prob. 1COQCh. 14 - Distinguish between spontaneous and induced...
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