ANATOMY+PHYSIOLOGY >CUSTOM<
9th Edition
ISBN: 2818440061721
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 14.3, Problem 5AYLO
The cerebellum: its location, gross anatomy, unique neuron types, its three pairs of peduncles, and their relationship to cerebellar input and output
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
ANATOMY+PHYSIOLOGY >CUSTOM<
Ch. 14.1 - Prob. 1BYGOCh. 14.1 - Define gyrus and sulcus.Ch. 14.1 - Prob. 3BYGOCh. 14.1 - Prob. 4BYGOCh. 14.1 - Prob. 1AYLOCh. 14.1 - Prob. 2AYLOCh. 14.1 - Prob. 3AYLOCh. 14.1 - Prob. 4AYLOCh. 14.1 - Prob. 5AYLOCh. 14.1 - Embryonic development of the brain from neural...
Ch. 14.2 - Prob. 5BYGOCh. 14.2 - Prob. 6BYGOCh. 14.2 - Prob. 7BYGOCh. 14.2 - Prob. 8BYGOCh. 14.2 - Prob. 1AYLOCh. 14.2 - Prob. 2AYLOCh. 14.2 - Prob. 3AYLOCh. 14.2 - Prob. 4AYLOCh. 14.2 - Prob. 5AYLOCh. 14.2 - Prob. 6AYLOCh. 14.2 - Prob. 7AYLOCh. 14.3 - Prob. 9BYGOCh. 14.3 - Prob. 10BYGOCh. 14.3 - Prob. 11BYGOCh. 14.3 - Prob. 12BYGOCh. 14.3 - Prob. 13BYGOCh. 14.3 - The medulla oblongata: its location, gross...Ch. 14.3 - Prob. 2AYLOCh. 14.3 - Prob. 3AYLOCh. 14.3 - Prob. 4AYLOCh. 14.3 - The cerebellum: its location, gross anatomy,...Ch. 14.3 - Prob. 6AYLOCh. 14.4 - Prob. 14BYGOCh. 14.4 - Prob. 15BYGOCh. 14.4 - List at least six functions of the hypothalamus.Ch. 14.4 - Prob. 17BYGOCh. 14.4 - Distinguish between commissural, association, and...Ch. 14.4 - Prob. 19BYGOCh. 14.4 - Prob. 20BYGOCh. 14.4 - Prob. 1AYLOCh. 14.4 - Prob. 2AYLOCh. 14.4 - Prob. 3AYLOCh. 14.4 - Prob. 4AYLOCh. 14.4 - Prob. 5AYLOCh. 14.4 - Prob. 6AYLOCh. 14.4 - Prob. 7AYLOCh. 14.4 - Prob. 8AYLOCh. 14.4 - Prob. 9AYLOCh. 14.4 - Prob. 10AYLOCh. 14.4 - Prob. 11AYLOCh. 14.4 - Prob. 12AYLOCh. 14.4 - Prob. 13AYLOCh. 14.5 - Prob. 21BYGOCh. 14.5 - Prob. 22BYGOCh. 14.5 - Prob. 23BYGOCh. 14.5 - Prob. 24BYGOCh. 14.5 - Prob. 1AYLOCh. 14.5 - Stages of sleep; physiological characteristics of...Ch. 14.5 - Association areas of the cerebral cortex; the...Ch. 14.5 - Prob. 4AYLOCh. 14.5 - Prob. 5AYLOCh. 14.5 - Prob. 6AYLOCh. 14.5 - Prob. 7AYLOCh. 14.5 - Prob. 8AYLOCh. 14.5 - Prob. 9AYLOCh. 14.5 - Prob. 10AYLOCh. 14.5 - Prob. 11AYLOCh. 14.5 - Effect of Parkinson disease and basal nuclei...Ch. 14.5 - Prob. 13AYLOCh. 14.5 - Prob. 14AYLOCh. 14.6 - Prob. 25BYGOCh. 14.6 - Prob. 26BYGOCh. 14.6 - Prob. 27BYGOCh. 14.6 - Prob. 28BYGOCh. 14.6 - Prob. 29BYGOCh. 14.6 - Prob. 1AYLOCh. 14.6 - Prob. 2AYLOCh. 14.6 - Prob. 3AYLOCh. 14.6 - Prob. 4AYLOCh. 14 - Which of these is caudal to the hypothalamus? a....Ch. 14 - If the telencephalon was removed from a 5-week-old...Ch. 14 - The blood-CSF barrier is formed by a. blood...Ch. 14 - Prob. 4TYRCh. 14 - Which of the following does not receive any input...Ch. 14 - Prob. 6TYRCh. 14 - Prob. 7TYRCh. 14 - The_________is most closely associated with the...Ch. 14 - Prob. 9TYRCh. 14 - Prob. 10TYRCh. 14 - The right and left cerebral hemispheres are...Ch. 14 - Prob. 12TYRCh. 14 - Prob. 13TYRCh. 14 - Prob. 14TYRCh. 14 - Prob. 15TYRCh. 14 - Prob. 16TYRCh. 14 - Prob. 17TYRCh. 14 - Prob. 18TYRCh. 14 - Prob. 19TYRCh. 14 - Prob. 20TYRCh. 14 - Prob. 1BYMVCh. 14 - Prob. 2BYMVCh. 14 - Prob. 3BYMVCh. 14 - Prob. 4BYMVCh. 14 - Prob. 5BYMVCh. 14 - Prob. 6BYMVCh. 14 - Prob. 7BYMVCh. 14 - oculo-Ch. 14 - Prob. 9BYMVCh. 14 - Prob. 10BYMVCh. 14 - Prob. 1WWTSCh. 14 - Prob. 2WWTSCh. 14 - Prob. 3WWTSCh. 14 - Prob. 4WWTSCh. 14 - Prob. 5WWTSCh. 14 - Prob. 6WWTSCh. 14 - Prob. 7WWTSCh. 14 - Prob. 8WWTSCh. 14 - Prob. 9WWTSCh. 14 - Prob. 10WWTSCh. 14 - Prob. 1TYCCh. 14 - Prob. 2TYCCh. 14 - Suppose that a neuroanatomist performed two...Ch. 14 - A person can survive destruction of an entire...Ch. 14 - Prob. 5TYC
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