ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
20th Edition
ISBN: 9781264303106
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 14, Problem 8CT
Summary Introduction
To determine:
The complications that might develop at later stages when an individual is accidently struck in the head.
Introduction:
In this case, Woody was accidently struck in the head with the bat of baseball. He fell to the ground and regained consciousness after some time. He was unable to recall or remember any of the events that happened even in the 10 minutes.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 14 Solutions
ANAT.+PHYSIO.1-LAB.MAN. >CUSTOM<
Ch. 14.1 - In general, into what three groups con sensory...Ch. 14.1 - List the eight major types of sensory receptors,...Ch. 14.1 - Prob. 3AYPCh. 14.1 - Prob. 4AYPCh. 14.1 - Prob. 5AYPCh. 14.1 - Prob. 6AYPCh. 14.1 - Prob. 7AYPCh. 14.1 - How do descending pathways modulate sensation?Ch. 14.1 - How are pain sensations localized? What is...Ch. 14.1 - Prob. 10AYP
Ch. 14.1 - Describe the spatial organization of the general...Ch. 14.1 - Prob. 12AYPCh. 14.2 - Prob. 13AYPCh. 14.2 - Prob. 14AYPCh. 14.2 - Prob. 15AYPCh. 14.2 - Prob. 16AYPCh. 14.2 - What two tracts form the direct pathways? What...Ch. 14.2 - Describe the location of the neurons in each...Ch. 14.2 - Name the structures and tracts that form the...Ch. 14.2 - Prob. 20AYPCh. 14.2 - Prob. 21AYPCh. 14.2 - What are the three functional parts of the...Ch. 14.2 - Explain the comparator activities of the...Ch. 14.2 - What are the general symptoms of cerebellar...Ch. 14.3 - Prob. 25AYPCh. 14.3 - Prob. 26AYPCh. 14.3 - Discuss the somatic motor output and reflexes from...Ch. 14.3 - Prob. 28AYPCh. 14.3 - Prob. 29AYPCh. 14.4 - Prob. 30AYPCh. 14.4 - Prob. 31AYPCh. 14.4 - Prob. 32AYPCh. 14.4 - Prob. 33AYPCh. 14.4 - What conditions produce alpha, beta, theta. and...Ch. 14.4 - Prob. 35AYPCh. 14.4 - Prob. 36AYPCh. 14.4 - Prob. 37AYPCh. 14.4 - Distinguish between declarative and procedural...Ch. 14.4 - Prob. 39AYPCh. 14.4 - Prob. 40AYPCh. 14.5 - Prob. 41AYPCh. 14.5 - Prob. 42AYPCh. 14.5 - Does aging always produce memory loss?Ch. 14 - Prob. 1RACCh. 14 - Prob. 2RACCh. 14 - Prob. 3RACCh. 14 - Prob. 4RACCh. 14 - Prob. 5RACCh. 14 - Prob. 6RACCh. 14 - Prob. 7RACCh. 14 - Prob. 8RACCh. 14 - Tertiary neurons in both the spinothalamic tract...Ch. 14 - Prob. 10RACCh. 14 - Prob. 11RACCh. 14 - Prob. 12RACCh. 14 - Prob. 13RACCh. 14 - Prob. 14RACCh. 14 - Prob. 15RACCh. 14 - Prob. 16RACCh. 14 - Prob. 17RACCh. 14 - Prob. 18RACCh. 14 - Which of these pathways is not an indirect...Ch. 14 - Prob. 20RACCh. 14 - The major effect of the basal nuclei is a. to act...Ch. 14 - Which part of the cerebellum is correctly matched...Ch. 14 - Prob. 23RACCh. 14 - Prob. 24RACCh. 14 - Prob. 25RACCh. 14 - The main connection between the right and left...Ch. 14 - Prob. 27RACCh. 14 - Prob. 28RACCh. 14 - Prob. 29RACCh. 14 - Prob. 30RACCh. 14 - Describe all the sensations and perceptions...Ch. 14 - Prob. 2CTCh. 14 - Prob. 3CTCh. 14 - Prob. 4CTCh. 14 - Prob. 5CTCh. 14 - Prob. 6CTCh. 14 - Prob. 7CTCh. 14 - Prob. 8CTCh. 14 - Prob. 9CT
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