Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 14, Problem 6TYK
The probability of tossing three coins simultaneously and obtaining three heads is
- a. ½.
- b. ¼.
- c. ⅛.
- d. ⅜.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
Study Guide for Campbell Biology
Ch. 14 - Fill in the following diagram of a cross of...Ch. 14 - A tall pea plant is crossed with a recessive dwarf...Ch. 14 - A true-breeding tall, purple-flowered pea plant...Ch. 14 - a. In the following cross, what is the probability...Ch. 14 - Prob. 5IQCh. 14 - Consider an example in which the M/m gene (for...Ch. 14 - The height of spike weed is a result of polygenic...Ch. 14 - Consider the following pedigree for the trait...Ch. 14 - a. What is the probability that a mating between...Ch. 14 - If two prospective parents both have siblings who...
Ch. 14 - Prob. 1SYKCh. 14 - How many different types of gametes can be formed...Ch. 14 - Prob. 3SYKCh. 14 - _______ gene Description a. has no effect on...Ch. 14 - _________ allele Description a. has no effect on...Ch. 14 - Prob. 3TYKMCh. 14 - Prob. 4TYKMCh. 14 - __________ dominant allele Description a. has no...Ch. 14 - __________ recessive allele Description a. has no...Ch. 14 - __________ genotype Description a. has no effect...Ch. 14 - Prob. 8TYKMCh. 14 - Prob. 9TYKMCh. 14 - Prob. 10TYKMCh. 14 - Prob. 11TYKMCh. 14 - Prob. 12TYKMCh. 14 - According to Mendels law of segregation, a. there...Ch. 14 - The F2 generation a. has a phenotypic ratio of...Ch. 14 - A 1:1 phenotypic ratio in a testcross indicates...Ch. 14 - Which phase of meiosis is most directly related to...Ch. 14 - After obtaining two heads from two tosses of a...Ch. 14 - The probability of tossing three coins...Ch. 14 - The probability of tossing three coins...Ch. 14 - In the F2 of a dihybrid cross involving two...Ch. 14 - In guinea pigs, the brown coat color allele (B) is...Ch. 14 - A true-breeding dwarf corn plant with red ears is...Ch. 14 - Prob. 11TYKCh. 14 - Prob. 12TYKCh. 14 - Prob. 13TYKCh. 14 - In humans, earwax can be wet or dry. The form of...Ch. 14 - You have blood type B, your mother has blood type...Ch. 14 - Prob. 16TYKCh. 14 - Summer squash are either white or yellow. To get...Ch. 14 - Prob. 2GPCh. 14 - True-breeding tall red-flowered plants are crossed...Ch. 14 - Prob. 4GPCh. 14 - Prob. 5GPCh. 14 - Prob. 6GPCh. 14 - Prob. 7GPCh. 14 - Prob. 8GPCh. 14 - Prob. 9GPCh. 14 - Fur color in rabbits is determined by a single...Ch. 14 - Prob. 11GPCh. 14 - The ability to taste phenylthiocarbamide (PTC) is...Ch. 14 - Prob. 13GPCh. 14 - Prob. 14GPCh. 14 - Prob. 15GPCh. 14 - Prob. 16GPCh. 14 - Imagine that a newly discovered, recessively...Ch. 14 - In mice, black fur (B) is dominant to white (b)....
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