Essential Cell Biology 5e
Essential Cell Biology 5e
5th Edition
ISBN: 9780393691108
Author: Bruce Alberts, Karen Hopkin, Alexander D Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Wa
Publisher: W. W. Norton
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Chapter 14, Problem 1Q
Summary Introduction

To explain: How dintrophenol (DNP) is effective in melting away the pounds, especially promoting the loss of fat reserves.

Introduction: The dinitrophenol is a small molecule that provides the membranes permeability to protons. It is a highly toxic compound and given to patients in small amounts to induce weight loss. It has various side effects, like elevation in temperature and excessive sweating.

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Explanation of Solution

The dinitrophenol or 2, 4-dintrophenol is a yellow, crystalline solid that has a sweet, musty odor. DNP was used extensively in diet pills because of the drugs have ability to greatly increase the metabolic rate. DNP has the ability to act as a protonophore, which means that they can allow the protons to leak across the inner mitochondrial membrane and thus bypass ATP synthases because of action of DNP, the ATP production will become less efficient and part of the energy that is normally produced in the body through cellular respiration is wasted as heat. When the dose of DNP increases, the energy production becomes more inefficient and the metabolic rate increases. This increases the metabolic rate that leads to the burning of fat and thus promoting the loss of fat reserves.

Summary Introduction

To explain: The unpleasant side reactions of patients during the treatment with DTP.

Introduction: The dinitrophenol is a small molecule that provides the membranes permeability to protons. It is a highly toxic compound and given to patients in small amounts to induce weight loss. It has various side effects, like elevation in temperature and excessive sweating.

Expert Solution
Check Mark

Explanation of Solution

DNP has the ability for uncoupling oxidative phosphorylation and it will lead to more heat production. Due to the amount of heat produced, there will be excessive rise in the body temperature and it can even cause fatal hyperthermia and diaphoresis. Hyperthermia is a condition in which the body temperature rises to as high as 44°C shortly before death and diaphoresis is an acute condition of excessive sweating.

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