Angiotensin is responsible for which of the following. Introduction: Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

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Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

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Answer 2

Question

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Expert Solution & Answer

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Answer 3

Question

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Expert Solution & Answer

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See solution

Answer 4

Question

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Answer 6

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Answer 7

Chapter 14, Problem 18RA

Summary Introduction

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Answer 8

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Answer 11

Ch. 14 - Prob. 1CP Ch. 14 - Prob. 2aCP Ch. 14 - Describe how the stroke volume is intrinsically...Ch. 14 - Define the terms preload and afterload and explain...Ch. 14 - Prob. 3CP Ch. 14 - Prob. 4aCP Ch. 14 - Define the term edema and describe four different...Ch. 14 - Prob. 5aCP Ch. 14 - Prob. 5bCP Ch. 14 - Prob. 5cCP

Angiotensin is responsible for which of the following. Introduction: Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Solution Summary: The author explains that angiotensin is a peptide hormone, which increases blood pressure and vasoconstriction, and regulates it and stimulates aldosterone.

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Want to see the full answer?

Chapter 14 Solutions

Angiotensin is responsible for which of the following. Introduction: Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Solution Summary: The author explains that angiotensin is a peptide hormone, which increases blood pressure and vasoconstriction, and regulates it and stimulates aldosterone.

To determine: Angiotensin is responsible for which of the following. Introduction: Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.

Want to see the full answer?

Chapter 14 Solutions

To determine:

Angiotensin is responsible for which of the following.

Introduction:

Angiotensin is a peptide hormone, which can increase blood pressure and vasoconstriction. It is also used to regulate the blood pressure and stimulate aldosterone. It is produced by the liver cells.