HUMAN ANATOMY PKG >CUSTOM<
8th Edition
ISBN: 9781323572528
Author: Marieb
Publisher: Pearson Custom Publishing
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Chapter 14, Problem 11RQ
Summary Introduction
To review:
The encapsulated nerve endings.
Introduction:
The sensory receptors innervate various somatic and visceral organs to sense temperature, pain, vibration, pressure, and stretch. They can be structurally classified into free nerve endings and encapsulated nerve endings. The free nerve ending is not an encapsulated structure and is the dendrite belonging to a sensory neuron.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
HUMAN ANATOMY PKG >CUSTOM<
Ch. 14 - Prob. 1CYUCh. 14 - Do all nerves contain both sensory and motor...Ch. 14 - Name the functional type of the sensory receptors...Ch. 14 - Are proprioceptors part of the somatic or visceral...Ch. 14 - Prob. 5CYUCh. 14 - Prob. 6CYUCh. 14 - Prob. 7CYUCh. 14 - Prob. 8CYUCh. 14 - Prob. 9CYUCh. 14 - Below which vertebra does each of the following...
Ch. 14 - Would a patient with a spinal injury at C5 be able...Ch. 14 - Prob. 12CYUCh. 14 - Prob. 13CYUCh. 14 - Prob. 14CYUCh. 14 - Prob. 15CYUCh. 14 - Using Hilton's law, identity the nerves that...Ch. 14 - Explain why a disc herniation at the level of...Ch. 14 - Shingles blisters that encircle the abdomen at the...Ch. 14 - Use your knowledge of word roots to define these...Ch. 14 - Does postpolio syndrome result from a dormant...Ch. 14 - Prob. 1RQCh. 14 - The large, onion-shaped pressure receptors in deep...Ch. 14 - Prob. 3RQCh. 14 - Prob. 4RQCh. 14 - Prob. 5RQCh. 14 - Which one of the following contains only motor...Ch. 14 - Prob. 7RQCh. 14 - Whereas bronchial refers to the airways in the...Ch. 14 - Which cranial nerves contain somatic motor axons...Ch. 14 - Which of the following components occur in all of...Ch. 14 - Prob. 11RQCh. 14 - Prob. 12RQCh. 14 - (a) Define nerve plexus. (b) List the spinal...Ch. 14 - ln the brachial plexus, what specific rami make up...Ch. 14 - Prob. 15RQCh. 14 - Choose the correct answer, and explain why it is...Ch. 14 - There are 40 roots in the cauda equina. To what...Ch. 14 - As Harry was falling off a ladder, he reached out...Ch. 14 - Frita, in her early 70s, had problems chewing....Ch. 14 - Ted is a war veteran who was hit in the back with...Ch. 14 - A quarterback suffered torn menisci in his right...Ch. 14 - In a patient who developed carpal tunnel syndrome,...Ch. 14 - Using Hiltoa’s law, (1) deduce which four nerves...Ch. 14 - After suffering from a broken humerus, a patient...Ch. 14 - Name all of the nerves that innervate the tongue.
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