Microbiology: A Systems Approach
4th Edition
ISBN: 9780073402437
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 13.3, Problem 21AYP
Summary Introduction
Toenlist:
The examples of emerging and reemerging infectious diseases
Concept introduction:
Emerging diseases are caused by microbes that have never been seen before. These diseases are caused by new microbes. Reemerging diseases are due to microorganisms that have become more prevalent in a population often due to increased virulence, travel, or due to lack of vaccination.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 13 Solutions
Microbiology: A Systems Approach
Ch. 13.1 - Prob. 1AYPCh. 13.1 - Identify the sites where normal biota is found in...Ch. 13.1 - Discuss how the Human Microbiome Project has...Ch. 13.2 - Prob. 2CFCh. 13.2 - Differentiate between a microbes pathogenicity and...Ch. 13.2 - Prob. 5AYPCh. 13.2 - List the steps a microbe has to take to get to the...Ch. 13.2 - Prob. 7AYPCh. 13.2 - Prob. 8AYPCh. 13.2 - Prob. 9AYP
Ch. 13.2 - Prob. 10AYPCh. 13.2 - Prob. 11AYPCh. 13.2 - Draw and label a curve representing the course of...Ch. 13.2 - Prob. 13AYPCh. 13.2 - List six different modes of horizontal...Ch. 13.2 - Define healthcare-associated infection, listing...Ch. 13.2 - List Kochs postulates, and explain alternative...Ch. 13.3 - Summarize the goals of epidemiology and the role...Ch. 13.3 - Identify why some diseases are notifiable, and...Ch. 13.3 - Prob. 19AYPCh. 13.3 - Discuss the three major types of epidemics, and...Ch. 13.3 - Prob. 21AYPCh. 13.3 - Prob. 22AYPCh. 13 - Prob. 1CFCh. 13 - Prob. 1MCQCh. 13 - Prob. 2MCQCh. 13 - Prob. 3MCQCh. 13 - Prob. 4MCQCh. 13 - Prob. 5MCQCh. 13 - Prob. 6MCQCh. 13 - Prob. 7MCQCh. 13 - Prob. 8MCQCh. 13 - A positive antibody test for HIV would be a...Ch. 13 - Prob. 10MCQCh. 13 - Prob. 11TFCh. 13 - Prob. 12TFCh. 13 - Prob. 13TFCh. 13 - Prob. 14TFCh. 13 - Prob. 15TFCh. 13 - Based upon data from the Human Microbiome Project...Ch. 13 - Prob. 2CTQCh. 13 - Prob. 3CTQCh. 13 - Prob. 4CTQCh. 13 - Prob. 5CTQCh. 13 - Prob. 6CTQCh. 13 - Prob. 7CTQCh. 13 - Prob. 8CTQCh. 13 - Prob. 9CTQCh. 13 - Prob. 10CTQCh. 13 - Prob. 1CCCh. 13 - Prob. 2CCCh. 13 - Prob. 3CCCh. 13 - Prob. 4CCCh. 13 - Prob. 5CCCh. 13 - Prob. 6CCCh. 13 - Prob. 1VCCh. 13 - Prob. 2VCCh. 13 - Appendix D provides guidance for working with...
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