Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 13, Problem 3TY
Transcription factors that bind to DNA and stimulate transcription are
- a. repressors.
- b. small effector molecules.
- c. activators.
- d. promoters.
- e. operators.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 13 Solutions
Biology
Ch. 13.1 - Prob. 1CCCh. 13.2 - Which genes are under the control of the lac...Ch. 13.2 - With regard to regulatory proteins and small...Ch. 13.2 - What were the key observations made by Jacob,...Ch. 13.2 - CoreSKILL What was the eventual hypothesis...Ch. 13.2 - Prob. 3EQCh. 13.2 - Core Skill: Connections Look back at Fig 9.12....Ch. 13.2 - What are the advantages of having both an...Ch. 13.2 - Prob. 4CCCh. 13.4 - Prob. 1CC
Ch. 13.4 - Prob. 2CCCh. 13.4 - Prob. 1BCCh. 13.6 - Prob. 1CCCh. 13.6 - Prob. 2CCCh. 13 - Prob. 1TYCh. 13 - Prob. 2TYCh. 13 - Transcription factors that bind to DNA and...Ch. 13 - Prob. 4TYCh. 13 - For the lac operon, what would be the expected...Ch. 13 - Prob. 6TYCh. 13 - The trp operon is considered _____ blank operon...Ch. 13 - Prob. 8TYCh. 13 - Prob. 9TYCh. 13 - _____ blank refers to the process that allows a...Ch. 13 - Prob. 1CQCh. 13 - Transcriptional regulation often involves a...Ch. 13 - Prob. 3CQCh. 13 - Discuss the advantages and disadvantages of...Ch. 13 - Discuss the advantages and disadvantages of...
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