The Immune System, 4th Edition
The Immune System, 4th Edition
4th Edition
ISBN: 9780815344667
Author: Peter Parham
Publisher: W. W. Norton & Company
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Chapter 13, Problem 3Q
Summary Introduction

(A)

To write:

How cytomegalovirus subverts the ability of MHC class I molecules.

Introduction:

Viruses depend on human metabolic products for their sustenance. Not only this they employ human biosynthetic pathways to replicate their genome and multiply. This obligatory nature of viruses makes it difficult for the immune system to fight against them. Cytomegalovirus is one such herpesvirus which causes opportunistic infections in HIV AIDS.

Summary Introduction

(B)

To write:

How cytomegalovirus subverts the ability of NK cell receptors to mediate immune responses.

Introduction:

NK cells are key modulators of immunity as they are involved in cytotoxicity. They are most important in viral infections as they produce interferon gamma (IFN-γ) against the viruses. They are said to holds some properties involving memory towards viral antigens which provides some degree of passive immunity. The cytomegalovirus downregulates NK cell receptors involved in the activation of NK cells.

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