The deletion or inactivation of SH3 domain that will alter the Src to be onogenic. Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

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Answer 1

Question

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

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Indicate for the reactions below which type of enzyme and cofactor(s) (if any) wouldbe required to catalyze each reaction shown. 1) Fru-6-P + Ery-4-P <--> GAP + Sed-7-P2) Fru-6-P + Pi <--> Fru-1,6-BP + H2O3) GTP + ADP <--> GDP + ATP4) Sed-7-P + GAP <--> Rib-5-P + Xyl-5-P5) Oxaloacetate + GTP ---> PEP + GDP + CO 26) DHAP + Ery-4-P <--> Sed-1,7-BP + H 2O7) Pyruvate + ATP + HCO3- ---> Oxaloacetate + ADP + Pi

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Answer 2

Question

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

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Answer 3

Question

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

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Answer 4

Question

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

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Answer 5

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

Answer 6

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

Answer 7

Chapter 13, Problem 25CQ

(a)

Summary Introduction

To explain: The deletion or inactivation of SH3 domain that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene. Src homology (SH)-2 domain allows the protein to sock itself with the phosphorylated tyrosine amino acid residues so the protein can phosphorylate other tyrosine residues.

Answer 8

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

Answer 9

(b)

Summary Introduction

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 13 - Prob. 1E Ch. 13 - 2. Retinoic acid (a derivative of vitamin A;...Ch. 13 - 3. What biochemical changes are required to...Ch. 13 - 4. The anabolic steroid methandrostenolone is...Ch. 13 - 5. Estimating the binding affinity of a ligand for...Ch. 13 - 6. Calculate the binding affinity of a ligand for...Ch. 13 - 7. Some bacterial signaling systems involve...Ch. 13 - 8. Why might a compound resembling ADP function as...Ch. 13 - 9. Explain why a protein tyrosine phosphatase...Ch. 13 - Prob. 10E

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To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

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Chapter 13 Solutions

Concept explainers

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To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic. Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.

Want to see the full answer?

Chapter 13 Solutions

To explain: The mutation of Tyr416 to Phe that will alter the Src to be onogenic.

Concept introduction: Src or c-Src is non-receptor tyrosine kinase protein that phosphorylates specific tyrosine amino acid residue. Src is a proto-oncogene.