FUNDAMENTALS OF BIOCHEMISTRY - LL FD
5th Edition
ISBN: 9781119598022
Author: Voet
Publisher: WILEY
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Chapter 13, Problem 23CQ
Summary Introduction
To explain: The way in which the features of the insulin receptor substrate that contains the pleckstrin homology, phosphotyrosine-binding homology, and phosphorylated six to eight tyrosine residues contribute to signal transduction.
Concept introduction: Pleckstrin homology (PH) domain helps to bind phosphate lipids to the lipid bilayer and also subunits of G-proteins and PKC. Tyrosine is an
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Given the values for the changes in enthalpy (AH) and entropy (AS), which processes can take place at 298 K without
violating the Second Law of Thermodynamics?
(a) AH =
(b) AH = -84 kJ mol¹ (−20 kcal mol¹), AS = -125 J mol-¹ K-¹ (-30 cal mol-¹ K-¹)
(c) AH = +84 kJ mol¹ (+20 kcal mol¯¹), AS = +125 J mol¯¹ K−¹ (+30 cal mol-¹ K-¹)
(d) AH = +84 kJ mol-1 (+20 kcal mol-¹), AS = -125 J mol¯¹ K-¹ (-30 cal mol-¹ K-¹)
-84 kJ mol¹ (-20 kcal mol¹), AS = +125 J mol¯¹ K-¹ (+30 cal mol-¹ K-¹)
What chemical interactions are primarily responsible for the fact that oil and water do not mix easily?
ionic interactions
covalent bonds
hydrogen bonding
Ohydrophobic effect
The carbon-nitrogen peptide bond is rigid, but rotation can take place
about the bond between the nitrogen and α-carbon atoms and the bond
between the α-carbon and the carbonyl carbon atom. These bond angles
define the conformation of the peptide chain.
Consider the Ramachandran plot shown to answer both questions.
(degrees)
180
120
60
60
0
Which observation most likely describes part of an observed a helix?
p=-59 degrees; = +150 degrees; many Ser residues
cp-140 degrees; w = +130 degrees; many Val residues
op-57 degrees; w = -47 degrees; many Pro residues
op-60 degrees; y = -47 degrees; many Ala residues
p = +60 degrees; y = +40 degrees; many Gly residues
-60
-120
-180
-180
0
➜ (degrees)
180
Chapter 13 Solutions
FUNDAMENTALS OF BIOCHEMISTRY - LL FD
Ch. 13 - Prob. 1ECh. 13 - 2. Retinoic acid (a derivative of vitamin A;...Ch. 13 - 3. What biochemical changes are required to...Ch. 13 - 4. The anabolic steroid methandrostenolone is...Ch. 13 - 5. Estimating the binding affinity of a ligand for...Ch. 13 - 6. Calculate the binding affinity of a ligand for...Ch. 13 - 7. Some bacterial signaling systems involve...Ch. 13 - 8. Why might a compound resembling ADP function as...Ch. 13 - 9. Explain why a protein tyrosine phosphatase...Ch. 13 - Prob. 10E
Ch. 13 - Prob. 11ECh. 13 - Prob. 12ECh. 13 - Prob. 13ECh. 13 - 14. Mycobacterium tuberculosis is an intracellular...Ch. 13 - Prob. 15ECh. 13 - Prob. 16ECh. 13 - Prob. 17ECh. 13 - Prob. 18ECh. 13 - Prob. 19ECh. 13 - 20. The SHP-2 protein participates in insulin...Ch. 13 - Prob. 21CQCh. 13 - Prob. 22CQCh. 13 - Prob. 23CQCh. 13 - Prob. 24CQCh. 13 - Prob. 25CQCh. 13 - Prob. 26CQCh. 13 - Prob. 27CQCh. 13 - Prob. 28CQCh. 13 - Prob. 29CQCh. 13 - Prob. 30CQCh. 13 - Prob. 31CQCh. 13 - Prob. 32CQCh. 13 - Prob. 1MTE
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