Chapter 13, Problem 23CQ

Summary Introduction

To explain: The way in which the features of the insulin receptor substrate that contains the pleckstrin homology, phosphotyrosine-binding homology, and phosphorylated six to eight tyrosine residues contribute to signal transduction.

Concept introduction: Pleckstrin homology (PH) domain helps to bind phosphate lipids to the lipid bilayer and also subunits of G-proteins and PKC. Tyrosine is an aromatic amino acid, and phosphorylation of the amino acid residue helps to activate the protein. Phosphotyrosine-binding (PTB) domains bind to the phosphorylated tyrosine residues.