(a) Interpretation: The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained. Concept introduction: Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Question

Want to see the full answer?

Answer 1

Question

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Examine the metabolic pathway. The enzymes that catalyze each step are identified as "e" with a numeric subscript. e₁ e3 e4 A B с 1° B' 02 e5 e6 e7 E F Which enzymes catalyze irreversible reactions? ப e ez ☐ ez e4 ☐ ப es 26 5 e7 Which of the enzymes is likely to be the allosteric enzyme that controls the synthesis of G? €2 ез e4 es 26 5 e7

An allosteric enzyme that follows the concerted model has an allosteric coefficient (T/R) of 300 in the absence of substrate. Suppose that a mutation reversed the ratio. Select the effects this mutation will have on the relationship between the rate of the reaction (V) and substrate concentration, [S]. ㅁㅁㅁ The enzyme would likely follow Michaelis-Menten kinetics. The plot of V versus [S] would be sigmoidal. The enzyme would mostly be in the T form. The plot of V versus [S] would be hyperbolic. The enzyme would be more active.

Penicillin is hydrolyzed and thereby rendered inactive by penicillinase (also known as ẞ-lactamase), an enzyme present in some penicillin-resistant bacteria. The mass of this enzyme in Staphylococcus aureus is 29.6 kDa. The amount of penicillin hydrolyzed in 1 minute in a 10.0 mL. solution containing 1.00 x 10 g of purified penicillinase was measured as a function of the concentration of penicillin. Assume that the concentration of penicillin does not change appreciably during the assay. Plots of V versus [S] and 1/V versus 1/[S] for these data are shown. Vo (* 10 M minute"¹) 7.0 6.0 5.0 4.0 3.0 20 1.0 0.0 о 10 20 30 1/Vo (* 10 M1 minute) 20 103 90 BO 70 50 [S] (* 100 M) 40 50 60 y=762x+1.46 × 10" [Penicillin] (M) Amount hydrolyzed (uM) 1 0.11 3 0.25 5 0.34 10 0.45 30 0.58 50 0.61

Answer 2

Question

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Answer 6

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Answer 7

Chapter 13, Problem 22P

Interpretation Introduction

(a)

Interpretation:

The factor by which an open to closed ratio increases by the binding of the firstacetylcholine molecule and the second acetylcholine molecule needs to be explained.

Concept introduction:

Acetylcholine act as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse. In other words, this enzyme causes rapid hydrolysis of acetylcholine.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The corresponding free energy contribution of the channel at 250C needs to be determined.

Concept introduction:

Acetylcholine act as a neurotransmitter which means it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, we can say that this enzyme causes rapid hydrolysis of acetylcholine.

Answer 10

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Answer 11

Interpretation Introduction

(c)

Interpretation:

Whether the allosteric transition be accounted for the MWC concerted mode or not needs to be explained.

Concept introduction:

Acetylcholine acts as a neurotransmitter which means, it sends messages or chemicals from one cell to another cell of the body. Acetylcholinesterase helps in stopping the excitation of a nerve cell after the transmission of impulse or in other words, one can say that this enzyme causes rapid hydrolysis of acetylcholine.

Answer 12

Expert Solution & Answer

Answer 13

Expert Solution & Answer

Answer 14

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 15

Ch. 13 - Prob. 1P Ch. 13 - Prob. 2P Ch. 13 - Prob. 3P Ch. 13 - Prob. 4P Ch. 13 - Prob. 5P Ch. 13 - Prob. 6P Ch. 13 - Prob. 7P Ch. 13 - Prob. 8P Ch. 13 - Prob. 9P Ch. 13 - Prob. 10P

Solution Summary: The author explains how an open to closed ratio increases by the binding of the first and second acetylcholine molecules.

Concept explainers

Want to see the full answer?

Chapter 13 Solutions