Chapter 13, Problem 1CS

Summary Introduction

To determine: The way in which mutation in hemoglobin β affects promoter, enhancer, and coding regions of the gene encoding hemoglobin β.

Introduction: The mutation in a β-hemoglobin gene can result in occurrence β thalassemia. β -thalassemia is a recessive trait that affects the oxygen-carrying capacity of the red blood cells (RBCs). This destroys RBCs and causes the availability of a huge amount of iron in the body. The iron starts depositing in the tissues and organs.