What happens when Neurospora spores are exposed to X-rays and a culture is established from the irradiated spores and then grown in (1) a minimal medium plus vitamins, (2) a minimal medium plus amino acids, and (3) a minimal medium. Introduction: Genes are sets of nucleotides that code for a particular protein. The genes have to be expressed for the synthesis of a protein. This gene expression is regulated depending on the requirement of the cell. For example, cell division proteins are synthesized prior to the cell division. Prokaryotic and eukaryotic genes have differential gene expression in order to suit the specific needs of the cell.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Chapter 13, Problem 17TYU

Summary Introduction

To explain: What happens when Neurospora spores are exposed to X-rays and a culture is established from the irradiated spores and then grown in (1) a minimal medium plus vitamins, (2) a minimal medium plus amino acids, and (3) a minimal medium.

Introduction: Genes are sets of nucleotides that code for a particular protein. The genes have to be expressed for the synthesis of a protein. This gene expression is regulated depending on the requirement of the cell. For example, cell division proteins are synthesized prior to the cell division. Prokaryotic and eukaryotic genes have differential gene expression in order to suit the specific needs of the cell.

Summary Introduction

To explain: What happens when Neurospora spores are exposed to X-rays and a culture is established from the irradiated spores and if the fungus does not grow in (1) a minimal medium plus vitamins, (2) a minimal medium plus amino acids, and (3) a minimal medium.

Introduction: Genes are sets of nucleotides that code for a particular protein. The genes have to be expressed for the synthesis of a protein. This gene expression is regulated depending on the requirement of the cell. For example, cell division proteins are synthesized prior to the cell division. Prokaryotic and eukaryotic genes have differential gene expression in order to suit the specific needs of the cell.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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