Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 12.3, Problem 17AYP
Summary Introduction
To determine:
The function and the mode of action of the complement system and interferon in one overview sentence.
Concept introduction:
Antimicrobial proteins are the larger proteins such as nutrient-binding proteins and they contain sites which targets specific microbial macromolecules. These proteins act largely by disrupting the structure or function of the cell membranes of the microbes.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 12 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 12.1 - Summarize the three lines of host defenses.Ch. 12.1 - Define marker and discuss its importance in the...Ch. 12.1 - Prob. 3AYPCh. 12.1 - Prob. 4AYPCh. 12.1 - Name three kinds of blood cells that function in...Ch. 12.1 - Connect the mononuclear phagocyte system to innate...Ch. 12.1 - Describe how T and B lymphocytes are involved in...Ch. 12.1 - Prob. 8AYPCh. 12.1 - Prob. 1MMCh. 12.1 - Prob. 1NP
Ch. 12.1 - Prob. 2MMCh. 12.2 - Prob. 9AYPCh. 12.2 - Prob. 10AYPCh. 12.2 - Prob. 11AYPCh. 12.2 - Prob. 2NPCh. 12.3 - List the four major categories of nonspecific...Ch. 12.3 - Prob. 13AYPCh. 12.3 - Prob. 14AYPCh. 12.3 - Prob. 15AYPCh. 12.3 - Name four types of antimicrobial host-derived...Ch. 12.3 - Prob. 17AYPCh. 12.3 - Prob. 3NPCh. 12.3 - NCLEX PREX 4. A patient presents to the emergency...Ch. 12.3 - Prob. 5NPCh. 12 - A microorganism carries _____ markers and a B cell...Ch. 12 - Prob. 2QCh. 12 - The pediatrician you work for has just recommended...Ch. 12 - Prob. 4QCh. 12 - In what way is a phagocyte a tiny container of...Ch. 12 - Prob. 6QCh. 12 - Prob. 7QCh. 12 - Prob. 8QCh. 12 - Explain the physiological events that lead to each...Ch. 12 - Prob. 10QCh. 12 - Prob. 11QCh. 12 - Prob. 12QCh. 12 - Prob. 13QCh. 12 - Why do you think that the intestines have one of...Ch. 12 - Prob. 15QCh. 12 - Prob. 16QCh. 12 - Prob. 17QCh. 12 - Prob. 18QCh. 12 - Figure 12.3 demonstrates that lymphatic fluid...Ch. 12 - Prob. 20QCh. 12 - Prob. 21QCh. 12 - Prob. 1VC
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