Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Chapter 12, Problem 7RQ
Summary Introduction
Introduction:
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 12 Solutions
Fundamentals of Anatomy & Physiology (11th Edition)
Ch. 12 - Describe the three anatomical divisions of the...Ch. 12 - Describe the two functional divisions of the...Ch. 12 - Identify the two components of the efferent...Ch. 12 - Prob. 4CPCh. 12 - Name the structural components of a typical...Ch. 12 - Classify neurons according to their structure.Ch. 12 - Classify neurons according to their function.Ch. 12 - Prob. 8CPCh. 12 - Prob. 9CPCh. 12 - Prob. 10CP
Ch. 12 - Prob. 11CPCh. 12 - Prob. 12CPCh. 12 - Prob. 13CPCh. 12 - What effect would decreasing the concentration of...Ch. 12 - Define action potential.Ch. 12 - Identify the steps involved in the generation and...Ch. 12 - Prob. 17CPCh. 12 - Which of the following axons is myelinated: one...Ch. 12 - Prob. 19CPCh. 12 - Prob. 20CPCh. 12 - What effect would blocking voltage-gated calcium...Ch. 12 - Prob. 22CPCh. 12 - Prob. 23CPCh. 12 - Prob. 24CPCh. 12 - Prob. 25CPCh. 12 - Prob. 26CPCh. 12 - Prob. 27CPCh. 12 - LEVEL 1 Reviewing Facts and Terms 1. Label the...Ch. 12 - Prob. 2RQCh. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - The neural cells responsible for the analysis of...Ch. 12 - Depolarization of a neuron plasma membrane will...Ch. 12 - Prob. 7RQCh. 12 - Receptors that bind acetylcholine at the...Ch. 12 - What are the major components of (a) the central...Ch. 12 - Prob. 10RQCh. 12 - Prob. 11RQCh. 12 - If the resting membrane potential of a neuron is...Ch. 12 - Prob. 13RQCh. 12 - What is the difference between anterograde flow...Ch. 12 - What is the functional difference among chemically...Ch. 12 - State the all-or-none principle cf action...Ch. 12 - Prob. 17RQCh. 12 - Prob. 18RQCh. 12 - What are the structural and functional differences...Ch. 12 - Describe the events that occur during nerve...Ch. 12 - Prob. 21RQCh. 12 - Prob. 22RQCh. 12 - Prob. 23RQCh. 12 - In multiple sclerosis, there is intermittent and...Ch. 12 - Prob. 25RQCh. 12 - Which cells of the CNS are targeted by the polio...Ch. 12 - Prob. 2CC
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