Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Textbook Question
Chapter 12, Problem 20RQ
Describe the events that occur during nerve impulse transmission at a typical cholinergic synapse.
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Describe the structure of a synapse, and explain the process of nerve impulse transmission at a synapse.
In the parasympathetic branch of the autonomic nervous system, there are two cholinergic synapses
(synapses mediated by acetylcholine) on the way to the target tissue. The first synapse is in the
autonomic ganglion (from the "preganglionic neuron"), and is always mediated by nicotinic
acetylcholine receptors (NACHRS). The second synapse (from the "postganglionic neuron") is on the
target cell, and is mediated by muscarinic acetylcholine receptors (mAChRs).
A. Which of these synapses is expected to always produce a rapid depolarization of the
postsynaptic cell? Explain your answer.
In the parasympathetic branch of the autonomic nervous system, there are two cholinergic synapses
(synapses mediated by acetylcholine) on the way to the target tissue. The first synapse is in the
autonomic ganglion (from the "preganglionic neuron"), and is always mediated by nicotinic
acetylcholine receptors (NACHRS). The second synapse (from the "postganglionic neuron") is on the
target cell, and is mediated by muscarinic acetylcholine receptors (mAChRs).
C. Which synapse is expected to be blocked by removal of Ca2+ from the external solution?
Chapter 12 Solutions
Fundamentals of Anatomy & Physiology (11th Edition)
Ch. 12 - Describe the three anatomical divisions of the...Ch. 12 - Describe the two functional divisions of the...Ch. 12 - Identify the two components of the efferent...Ch. 12 - Prob. 4CPCh. 12 - Name the structural components of a typical...Ch. 12 - Classify neurons according to their structure.Ch. 12 - Classify neurons according to their function.Ch. 12 - Prob. 8CPCh. 12 - Prob. 9CPCh. 12 - Prob. 10CP
Ch. 12 - Prob. 11CPCh. 12 - Prob. 12CPCh. 12 - Prob. 13CPCh. 12 - What effect would decreasing the concentration of...Ch. 12 - Define action potential.Ch. 12 - Identify the steps involved in the generation and...Ch. 12 - Prob. 17CPCh. 12 - Which of the following axons is myelinated: one...Ch. 12 - Prob. 19CPCh. 12 - Prob. 20CPCh. 12 - What effect would blocking voltage-gated calcium...Ch. 12 - Prob. 22CPCh. 12 - Prob. 23CPCh. 12 - Prob. 24CPCh. 12 - Prob. 25CPCh. 12 - Prob. 26CPCh. 12 - Prob. 27CPCh. 12 - LEVEL 1 Reviewing Facts and Terms 1. Label the...Ch. 12 - Prob. 2RQCh. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - The neural cells responsible for the analysis of...Ch. 12 - Depolarization of a neuron plasma membrane will...Ch. 12 - Prob. 7RQCh. 12 - Receptors that bind acetylcholine at the...Ch. 12 - What are the major components of (a) the central...Ch. 12 - Prob. 10RQCh. 12 - Prob. 11RQCh. 12 - If the resting membrane potential of a neuron is...Ch. 12 - Prob. 13RQCh. 12 - What is the difference between anterograde flow...Ch. 12 - What is the functional difference among chemically...Ch. 12 - State the all-or-none principle cf action...Ch. 12 - Prob. 17RQCh. 12 - Prob. 18RQCh. 12 - What are the structural and functional differences...Ch. 12 - Describe the events that occur during nerve...Ch. 12 - Prob. 21RQCh. 12 - Prob. 22RQCh. 12 - Prob. 23RQCh. 12 - In multiple sclerosis, there is intermittent and...Ch. 12 - Prob. 25RQCh. 12 - Which cells of the CNS are targeted by the polio...Ch. 12 - Prob. 2CC
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- In the parasympathetic branch of the autonomic nervous system, there are two cholinergic synapses (synapses mediated by acetylcholine) on the way to the target tissue. The first synapse is in the autonomic ganglion (from the "preganglionic neuron"), and is always mediated by nicotinic acetylcholine receptors (NACHRS). The second synapse (from the "postganglionic neuron") is on the target cell, and is mediated by muscarinic acetylcholine receptors (mAChRs). B. One of these synapses produces a long-lasting hyperpolarization of its target cell. Which synapse, and why?arrow_forwardDescribe how neurotransmission occurs across a chemical synapse, using acetylcholine as an example.arrow_forwardthe bacterium clostridium tetani produce a toxin called tetanospasmin, the causative agent os the disease tetanus. the toxin prevents the release of inhibitory transmitters in the CNS and so blocks the resulting IPSPs they would normally generate. what are some of the functions of inhibitory synapses? considering this what symptoms would you expect from the disease tetanus, and why? ( hint: imagine trying to stand up if all of the muscles in your lower limb contracted at the same time.)arrow_forward
- Name the neurotransmitter released at each synapse orneuroeffector junction in the somatic and autonomic system?arrow_forwardWhat effect would blocking calcium ion channels at a cholinergic synapse have on synapse function?arrow_forwardName the neurotransmitter released at each synapse or neuroeffector junction in the somatic and autonomic systems?arrow_forward
- Match the following statements to the correct neurotransmitter of the autonomic nervous system. Select "Both" if the statement is true of both neurotransmitters. Secreted by cholinergic fibers. Receptors for this neurotransmitter may cause either excitatory or inhibitory responses. Bind(s) to adrenergic receptors. Receptors for this neurotransmitter are found on all autonomic postganglionic neurons. This neurotransmitter can increase heart rate. ANSWER OPTIONS: Acetylcholine or Norepinephrine? Both?arrow_forwardList the three neurotransmitters involved in the basal ganglia and explain their role.arrow_forwardNervous system functions that directly employ acetylcholine neurotransmitters are referred to as cholinergic. Drugs that might be therapeutic in treating the symptoms of dopamine loss in Parkinson’s disease could include multiple choice 1 dopaminergic agonists and cholinergic antagonists. dopaminergic antagonists and cholinergic antagonists. dopaminergic antagonists and cholinergic agonists. dopaminergic agonists and cholinergic agonists. 2. From the information provided, drugs used to treat Parkinson’s disease symptoms will act at which location? multiple choice 2 The globus pallidus The substantia nigra The striatum 3. Which of the following might be therapeutic in the treatment of Parkinson’s disease symptoms? multiple choice 3 all of these choices listed may be therapeutic increasing dopamine receptor responsiveness monoamine oxidase inhibition increasing dopamine release decreasing dopamine…arrow_forward
- Chemicals such as organophosphate pesticides inhibit the activity of acetylcholine esterase. What effect would they have on the synapse?arrow_forwardlist at least eight ways in which the effectiveness of synapses may be altered and explain each pointarrow_forwardExplain how monoamines are inactivated at the synapse and how this process can be clinically manipulated.arrow_forward
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