HUMAN A+P MOD.MASTERING
2nd Edition
ISBN: 9780136919520
Author: AMERMAN
Publisher: PEARSON
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Chapter 1.2, Problem 5QC
How are physiological specializations classified?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
HUMAN A+P MOD.MASTERING
Ch. 1.1 - What are some examples of learning modalities?Ch. 1.1 - 2. How should you approach reading a textbook,...Ch. 1.1 - What are some study strategies to improve your...Ch. 1.1 - Prob. 4QCCh. 1.1 - 5. What are some strategies for taking good notes...Ch. 1.1 - 6. How can you use the features found in each...Ch. 1.1 - 7. How should you approach the study of figures...Ch. 1.2 - What are the properties common to all living...Ch. 1.2 - Prob. 2QCCh. 1.2 - 3. What are the 11 organ systems in the body?
Ch. 1.2 - 4. How do gross anatomy and microscopic anatomy...Ch. 1.2 - How are physiological specializations classified?Ch. 1.3 - What is anatomical position?Ch. 1.3 - Fill in the blanks: The nose is to the mouth....Ch. 1.3 - Fill in the blanks: a. The wrist is also known as...Ch. 1.3 - How do the three main planes of section differ?Ch. 1.4 - What are the two subcavities of the posterior body...Ch. 1.4 - 2. List the subdivisions of the thoracic and...Ch. 1.4 - 3. What are serous membranes, and what are their...Ch. 1.4 - Explain how serous membranes form certain anterior...Ch. 1.5 - 1. What is homeostasis, and why is it important?
Ch. 1.5 - 2. What is a homeostatic imbalance?
Ch. 1.5 - How do negative feedback loops maintain...Ch. 1.5 - Prob. 4QCCh. 1.5 - Prob. 5QCCh. 1.5 - What is a gradient? What are some examples of...Ch. 1.5 - 7. Why is cell-cell communication important?
Ch. 1.5 - 8. What are the two major methods by which cells...Ch. 1 - Fill in the blanks: The study of the form of the...Ch. 1 - Mark the following statements as true or false. If...Ch. 1 - Prob. 3CYRCh. 1 - Prob. 4CYRCh. 1 - 5. Which of the following correctly describes the...Ch. 1 - Mark the following statements as true or false. If...Ch. 1 - Match the following terms with the correct...Ch. 1 - 8. The upper and lower limbs are known broadly as...Ch. 1 - The arm is known as the ___________ region; the...Ch. 1 - A parasagittal section divides the body or body...Ch. 1 - 11. Fill in the blanks: The two divisions of the...Ch. 1 - 12. Fill in the blanks: The two main divisions of...Ch. 1 - 13. In which of the following cavities do serous...Ch. 1 - 14. Serous fluid functions in:
a. Providing...Ch. 1 - 15. Which organs would you expect to find in the...Ch. 1 - 16. Mark the following statements as true or...Ch. 1 - Prob. 17CYRCh. 1 - Examine the structure of the skull, and predict...Ch. 1 - Prob. 2CYUCh. 1 - Prob. 1AYKCh. 1 - 2. During a procedure on Ms. Norman’s pancreas, a...Ch. 1 - Later that same day, the surgeon performs a...Ch. 1 - The baroreceptor reflex causes blood pressure to...
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