Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
10th Edition
ISBN: 9780133922851
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 12, Problem 4TYU

The decline of MPF activity at the end of mitosis is due to

(A) the destruction of the protein kinase Cdk.

(B) decreased synthesis of Cdk.

(C) the degradation of cyclin.

(D) the accumulation of cyclin.

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. 2 3 1 4 . 5 6 I 7. .. (a) Identify the point in mitosis at which separase cleaves the protein complex that holds sister chromatid pairs together. In normal cells, separase is kept in an inactive state until it is needed. Explain how the progression of cells past sequential cell cycle checkpoints and the activity of enzymes such as separase is controlled by interactions between two major groups of regulatory proteins. (b) Identify an independent variable in the experiment graphed in Figure 1. Based on the data in Figure 1, identify a control that shows that Sepin-1 rather than something else in the culture medium is inhibiting the growth of the cancer cells. (c) Based on the data in Table 1, describe the general relationship between the sensitivity of cells to Sepin-1 and the concentration of separase in the cells. Use the Figure 1 data to calculate the ratio between the amount of Sepin-1 required to kill 50% of the cells in the cell line that is most sensitive to the compound and the…

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Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)

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