BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
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Question
Chapter 12, Problem 18P
Interpretation Introduction
(a)
Interpretation:
The hypothesis for the different results of ibuprofen and indomethacin inhibitors should be determined.
Concept introduction:
The substances that are added in a reaction in order to slow down it or to prevent the formation of unwanted products are called inhibitors. These are just the opposite of catalysts. There are three types of inhibitors:
- Competitive inhibitors: These occupy the region where the substrate is to be placed and therefore it blocks the active site of the enzyme. Methotrexate is an example of a competitive inhibitor.
- Uncompetitive inhibitors: These bind to enzyme-substrate complex and therefore the enzyme becomes unable to react with the substrate. Lansoprazole is an example of an uncompetitive inhibitor.
- Non-competitive inhibitors: These bind to some region of the enzyme other than the active site and alter its shape. Phenethyl isothiocyanate is an example of a non-competitive inhibitor.
Interpretation Introduction
(b)
Interpretation:
The results with the use of aspirin should be determined.
Concept introduction:
The substances that are added in a reaction in order to slow it down or to prevent the formation of unwanted products are called inhibitors. These are just the opposite of catalysts. There are three types of inhibitors:
- Competitive inhibitors: These occupy the region where the substrate is to be placed and therefore it blocks the active site of the enzyme. Methotrexate is an example of a competitive inhibitor.
- Uncompetitive inhibitors: These bind to enzyme-substrate complex and therefore the enzyme becomes unable to react with the substrate. Lansoprazole is an example of an uncompetitive inhibitor.
- Non-competitive inhibitors: These bind to some region of the enzyme other than the active site and alter its shape. Phenethyl isothiocyanate is an example of a noncompetitive inhibitor.
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9. Which one of the compounds below is the major organic product obtained from
the following reaction sequence, starting with ethyl acetoacetate?
요요.
1. NaOCH2CH3
CH3CH2OH
1. NaOH, H₂O
2. H3O+
3. A
OCH2CH3
2.
ethyl acetoacetate
ii
A
3. H3O+
OH
B
C
D
E
7. Only one of the following ketones cannot be made via an acetoacetic ester
synthesis. Which one is it?
Ph
کہ
A
B
C
D
E
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