Anatomy & Physiology (6th Edition)
6th Edition
ISBN: 9780134156415
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Chapter 11, Problem 9MC
Inhibition of acetylcholinesterase by poisoning blocks neurotransmission at the neuromuscular junction because (a) Ach is no longer release by the presynaptic terminal, (b) Ach synthesis in the presynaptic terminal is blocked, (c) Ach is not degraded, hence prolonged depolarization is enforced on the postsynaptic cell, (d) Ach is blocked from attaching to the postsynaptic Ach receptors.
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Select the best answer or answers from the choices given: Inhibition of acetylcholinesterase by poisoning blocks neurotransmission at the neuromuscular junction because (a) ACh is no longer released by the presynaptic terminal, (b) ACh synthesis in the presynaptic terminal is blocked, (c) ACh is not degraded, hence prolonged depolarization is enforced onthe postsynaptic cell, (d) ACh is blocked from attaching to the postsynaptic ACh receptors.
Put the following events in chronological order. (Some of the steps may be missing.)1) Ca*+ floods into the pre-synaptic neuron.2) ch (Acetylcholine) binds to ACh receptors in the sarcolemma.3) Na+ floods into the post-synaptic muscle cell.4) The A.P arrives at the pre-synaptic terminal causing Ca+ channels to open.5) Ach from the synaptic vesicles spills into the pre-synaptic cleft.6) A post-synaptic action potential results in the muscle fiber (depolarization
Describe the effect of the botulinum toxin, which inhibits the release of acetylcholine at the neuromuscular junction. Would the poison curare, which competes for acetylcholine receptors (by attaching to the acetylcholine receptors and preventing acetylcholine from binding) have a similar effect? Explain
Chapter 11 Solutions
Anatomy & Physiology (6th Edition)
Ch. 11.1 - What is meant by integration, and does it...Ch. 11.1 - Which subdivision of the PNS is involved in (a)...Ch. 11.2 - Which type of neuroglia controls the extracellular...Ch. 11.2 - Which two types of neuroglia form insulating...Ch. 11.3 - How does a nucleus within the brain differ from a...Ch. 11.3 - How is a myelin sheath formed in the CNS, and what...Ch. 11.3 - Which structural and functional type of neuron is...Ch. 11.3 - MAKING CONNECTIONS Which part of the neuron is its...Ch. 11.4 - For an open channel, what factors determine in...Ch. 11.4 - Prob. 10CYU
Ch. 11.5 - What determines the size of a graded potential?Ch. 11.6 - Which is bigger, a graded potential or an action...Ch. 11.6 - An action potential does not get smaller as it...Ch. 11.6 - Why does a myelinated axon conduct action...Ch. 11.6 - If an axon receives two stimuli close together in...Ch. 11.7 - Events at a chemical synapse usually involve...Ch. 11.7 - What structure joins two neurons at an electrical...Ch. 11.8 - Which ions flow through chemically gated channels...Ch. 11.8 - Prob. 19CYUCh. 11.9 - Prob. 20CYUCh. 11.9 - Why is cyclic AMP called a second messenger?Ch. 11.10 - Which types of neural circuits would give a...Ch. 11.10 - Prob. 23CYUCh. 11.10 - What pattern of neural processing occurs when we...Ch. 11 - Which of the following structures is not part of...Ch. 11 - Match the names of the supporting cells found in...Ch. 11 - Assume that an EPSP is being generated on the...Ch. 11 - Prob. 3MCCh. 11 - The velocity of nerve impulse conduction is...Ch. 11 - Chemical synapses are characterized by all of the...Ch. 11 - Biogenic amine neurotransmitters include all but...Ch. 11 - Prob. 8MCCh. 11 - Inhibition of acetylcholinesterase by poisoning...Ch. 11 - The anatomical region of a multipolar neuron where...Ch. 11 - An IPSP is inhibitory because (a) it...Ch. 11 - Identify the neuronal circuits described by...Ch. 11 - Explain both the anatomical and functional...Ch. 11 - (a) Describe the composition and function of the...Ch. 11 - (a) What is myelin? (b) How does the myelination...Ch. 11 - (a) Contrast unipolar, bipolar, and multipolar...Ch. 11 - What is the polarized membrane state? How is it...Ch. 11 - Describe the events that must occur to generate an...Ch. 11 - Prob. 19SAQCh. 11 - (a) Explain the difference between an EPSP and an...Ch. 11 - Since at any moment a neuron is likely to have...Ch. 11 - The effects of neurotransmitter binding are very...Ch. 11 - Prob. 23SAQCh. 11 - Prob. 24SAQCh. 11 - Elaine Sawyer, 35, was on her way to the local...Ch. 11 - Elaine Sawyer, 35, was on her way to the local...Ch. 11 - Elaine Sawyer, 35, was on her way to the local...Ch. 11 - Elaine Sawyer, 35, was on her way to the local...Ch. 11 - Elaine Sawyer, 35, was on her way to the local...
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- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.arrow_forwardCalcium entry through NNDA receptor can potentiate synaptic transmission through the following mechanisms EXCEPT: a.) Insertion of AMPA receptors to postsynaptic membrane b.) Synthesis of NO to increase presynaptic transmitter release c.) Phosphorylation of AMPA receptors d.) Slowing down glutamate reupdate, so it remains longer in the synapsearrow_forwardSuccinylcholine act as adepolarising agent that prevents repolarization of the somatic motor neuron. Thus, no further ACh is released until drug is cleared. Name another site within the MNJ we could target to prevent muscle contraction, and explain why this would work.arrow_forward
- The neuromuscular junction is similar to synapses in the central nervous system in that: (SELECT ALL THAT APPLY) a.) A wave of depolarization in the presynaptic terminal opens voltage gated Ca++ channels b.) Calcium entry through voltage-gated channels in the presynaptic terminal is necessary for the release of neurotransmitter c.) The neurotransmitter released from the pre-synaptic terminal binds to specific receptors on the post-synaptic side d.) The release at the neuromuscular junction of acetylcholine results in just a fraction of a mV depolarization on the post-synaptic membrane which is similar to what is seen at synapses in the central nervous system.arrow_forwardIn Neurology, please explain the relationship between suprathreshold depolarization and induced electrical neuro transmission. Is suprathreshold depolarization essential for inducing the electrical transmission?please explain in a few sentences.arrow_forwardA synapse between a terminal bouton and a neuron cell body is classified as (a) axodendritic, (b) axoaxonic, (c) axosomatic, (d) axoneuronic.arrow_forward
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