Chapter 11, Problem 13PIAT

Summary Introduction

To review:

The given organization of the signal transduction pathway mediated by scaffold protein affects the speed of the response and amplification of the signal.

Introduction:

Signal transduction is the cellular process involving binding of signaling molecule to a receptor present on cell surface and transmission of signal through the cell triggering a cascade of events inside the cell. Scaffold proteins play essential role in regulating many key signaling pathways by bringing two protein molecules together in close proximity to attain stable configuration through protein–protein interactions. Few intracellular proteins involved in the pheromone-activated response in yeast are organized by a scaffold protein called Ste5. When pheromone binding occurs, one of these proteins, called Fus3 is released from Ste5 and triggers the cellular response.