Chapter 11, Problem 11P

A.

Summary Introduction

To determine: The kinds of cation channels that respond to acetylcholine shown by patch-clamp measurements in the young rat muscles (Fig. Q11-4).

Concept introduction: Neurotransmitter is a chemical messenger that binds to the receptors present on the postsynaptic neuron. Acetylcholine is a neurotransmitter that utilizes its action on the cell by binding and activating receptors present on the surface of cells. It works through acetylcholine-gated cation channels at the neuromuscular junction. These channels open in response to acetylcholine secreted by the nerve terminal and Na⁺ ions enter the muscle cell causing membrane depolarization. This results in contraction of muscles.

B.

Summary Introduction

To calculate: The number of ions that enter in one millisecond for each kind of channel.

Concept introduction: Neurotransmitter is a chemical messenger that binds to the receptors present on the postsynaptic neuron. Acetylcholine is a neurotransmitter that utilizes its action on the cell by binding and activating receptors present on the surface of cells. It works through acetylcholine-gated cation channels at the neuromuscular junction. These channels open in response to acetylcholine secreted by the nerve terminal and Na⁺ ions enter the muscle cell causing membrane depolarization. This results in contraction of muscles.