GENETIC ANALYSIS: AN INTEG. APP. W/MAS
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Chapter 10, Problem 3P

Compare and contrast the contributions of Neel, Pauling, and Ingram to our understanding of the genetic and molecular bases of sickle cell disease.

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Mad cow disease, or bovine spongiform encephalopathy, appears to be caused by a novel infectious agent: a protein that replicates by causing related proteins to modify their structure from a harmless shape to a dangerous one. These prions (short for “proteinaceous infectious particles”) also appear to be the cause of several other spongiform encephalopathy diseases, such as scrapie in sheep, and kuru and Creutzfeldt-Jakob disease in humans. Which of the following observations or experiments would not support the hypothesis that a prion causes spongiform encephalopathy? (a) The brains of many sheep with scrapie contain prion proteins, but the brains of most sheep without scrapie do not. (b) There is a high incidence of kuru in populations of people who consume brain tissue from prion-infected animals. (c) Coyotes that feed on cows with mad cow disease do not subsequently develop spongiform encephalopathy. (d) When introduced into sheep brain cells in culture, prions cause the normal…
What are some possible reasons that researchers might be interested in identifying the gene that causes a genetic disease such as ICA? In other words, what benefits might result from this research?

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