Chapter 10, Problem 3IA.4Q

Summary Introduction

To determine:

The type of inhibition which is an example of an enzyme hexokinase which catalyzes the first step in glycolysis: $\text{glucose}\to \text{glucose}-6-\text{phosphate}$

Introduction:

During glycolysis, the conversion of glucose to glucose-6- phosphate is catalyzed by the enzyme hexokinase. The building up of the product glucose-6-phosphate inhibited the activity of the enzyme hexokinase. The binding of glucose-6-phosphate to a second site on the enzyme changes the shape of the active site.