Chemistry in Context
Chemistry in Context
8th Edition
ISBN: 9780073522975
Author: American Chemical Society
Publisher: McGraw-Hill Education
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Chapter 10, Problem 37Q
Interpretation Introduction

Interpretation:

Chiral carbon in L-DOPA has to be identified and the reason for why L-DOPA is effective against the muscular rigidity and the tremors related with Parkinson’s disease whereas D-DOPA is not has to be explained.

Concept Introduction:

Drugs: Drugs are molecules which are taken from an external source to change the normal functioning of the body. The action of drug is in molecular level and the design of many drugs are in such a way that it mimics a particular neurotransmitter or hormone. Drugs bind with receptors showing an increased or decreased effect.

Receptors: Receptors is a molecule or a part of molecule which interacts with a neurotransmitter, a hormone or other molecules which are biochemically active so that a response is initiated in a target cell.

Chirality: It refers to a Carbon atom in a molecule that contains four different substituents.

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Sinemet, the trade name of a drug used to treat Parkinson's disease, contains a combination of L-dopa and carbidopa. Carbidopa increases the effectiveness of L-dopa by inhibiting its metabolism prior to crossing the blood-brain barrier and entering the brain. Answer the following question about L-dopa. HO HO. H NH2 Но L-dopa a. Convert the skeletal structure to a Kekulé structure. (Don't forget the lone pairs) b. What is the hybridization and geometry around each highlighted atom? C. Label three polar bonds.
Explain step 5 in the question (what lessons can be learned from this) - the drug is thalidomide
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Chemistry in Context

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