EP MICROBIOLOGY:W/DISEASES BY..-MOD.ACC
5th Edition
ISBN: 9780134607894
Author: BAUMAN
Publisher: PEARSON CO
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Chapter 10, Problem 2TMW
Some antimicrobial drugs are harmful to humans. Why can physicians use such drugs despite the potential danger?
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
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Chapter 10 Solutions
EP MICROBIOLOGY:W/DISEASES BY..-MOD.ACC
Ch. 10 - Prob. 1TMWCh. 10 - Some antimicrobial drugs are harmful to humans....Ch. 10 - Antibiotic Overkill A young woman was taking...Ch. 10 - Prob. 2CCSCh. 10 - Prob. 3TMWCh. 10 - Why is it incorrect to say that an individual...Ch. 10 - Prob. 1EDCSCh. 10 - Prob. 3CCSCh. 10 - Prob. 1MCCh. 10 - In a Kirby-Bauer susceptibility test, the presence...
Ch. 10 - Prob. 3MCCh. 10 - Prob. 4MCCh. 10 - Cross resistance is _____. a. the deactivation of...Ch. 10 - Prob. 6MCCh. 10 - Prob. 7MCCh. 10 - Prob. 8MCCh. 10 - Prob. 9MCCh. 10 - Prob. 10MCCh. 10 - Label each figure below to indicate the class of...Ch. 10 - What specific test for antimicrobial efficacy is...Ch. 10 - What characteristics would an ideal...Ch. 10 - Prob. 2SACh. 10 - Why is the fact that drug Z destroys the NAM...Ch. 10 - Given that both human cells and pathogens...Ch. 10 - Prob. 5SACh. 10 - Prob. 6SACh. 10 - Prob. 7SACh. 10 - Prob. 8SACh. 10 - Compare and contrast the actions of polyenes,...Ch. 10 - Prob. 10SACh. 10 - Prob. 1CTCh. 10 - How does Penicillium escape the effects of the...Ch. 10 - How might a colony of Bacillus licheniformis...Ch. 10 - Fewer than 1 % of known antibiotics have any...Ch. 10 - In an issue of News of the Lepidopterists Society,...Ch. 10 - Even though aminoglycosides such as gentamicin can...Ch. 10 - Prob. 7CTCh. 10 - Prob. 8CTCh. 10 - Why might amphotericin B affect the kidneys more...Ch. 10 - Antiparasitic drugs in the benzimidazole family...Ch. 10 - Prob. 11CTCh. 10 - Scientists have cultured bacteria isolated from...Ch. 10 - Prob. 13CTCh. 10 - Prob. 14CTCh. 10 - Enterococcus faecium is frequently resistant to...Ch. 10 - Prob. 1CM
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