Chapter 10, Problem 2AYKA

Summary Introduction

To review:

The predictable effects of drug neostigmine, known to block the activity of enzyme AchE(acetylcholinesterase) in the synaptic cleft.

Introduction:

The neurotransmitter, acetylcholine (Ach), is involved in muscle contraction as it is released by the presynaptic neuron and binds to receptors on the postsynaptic membrane. This opens the ion channels and generates an excitatory or inhibitory potential in the postsynaptic membrane. Ach is degraded by an enzyme called AchE (acetylcholinesterase), which is present in the synaptic cleft.