Chapter 10, Problem 10.22P

Interpretation Introduction

Interpretation:

The structure of acyl phosphate and its ionization state at physiological pH is to be stated. An explanation for the interaction of phosphate group with ${\text{Mg}}^{\text{2+}}$ ions or hydrogen-bonding sites at active site of enzyme enhances the reactivity of acyl phosphates is to stated.

Concept introduction:

The nucleophilic substitution reactions are the reactions in which a group is substituted by an incoming nucleophile. These rate of reaction depend upon the nucleophilicity and concentration of the incoming nucleophile.

The ${\text{S}}_{\text{N}}\text{2}$ reaction is a nucleophilic substitution bimolecular reaction in which the addition of incoming nucleophile and elimination of a leaving group takes place simultaneously. The rate of reaction depends upon both the substrate and reactant in the rate law equation.