The use of the given experiment as a support by the research organization to gain funding. The research proposed by them is the long-term research to develop a continuous pipeline of new drugs and antibiotics. Given: In the given experiment, the researchers use a serial transfer for propagating 1,255 population of Escherichia coli in gradually increasing antibiotic (rifampicin) concentration environment. In the figure B the results of the experiments depicting the percentage of population surviving the antibiotic conditions are shown. Introduction: Antibiotic resistance is the phenomena where the bacteria can evade the attack by antibiotics by acquiring drug resistance plasmids and genes through horizontal or lateral gene transfer. The continuous feeding or the gradual increase in antibiotics provides the bacteria a path to accumulate point mutations, undergo genetic recombination and eventually end up becoming a multidrug resistant (MDR) strain.

Question

Want to see the full answer?

Answer 1

Question

Chapter 1, Problem 5Q

Summary Introduction

To analyze:

The use of the given experiment as a support by the research organization to gain funding. The research proposed by them is the long-term research to develop a continuous pipeline of new drugs and antibiotics.

Given:

In the given experiment, the researchers use a serial transfer for propagating 1,255 population of Escherichia coli in gradually increasing antibiotic (rifampicin) concentration environment.

In the figure B the results of the experiments depicting the percentage of population surviving the antibiotic conditions are shown.

Introduction:

Antibiotic resistance is the phenomena where the bacteria can evade the attack by antibiotics by acquiring drug resistance plasmids and genes through horizontal or lateral gene transfer. The continuous feeding or the gradual increase in antibiotics provides the bacteria a path to accumulate point mutations, undergo genetic recombination and eventually end up becoming a multidrug resistant (MDR) strain.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

What is an original research? Do you think the following are ideas that may be considered as original? Support your answer with logical reasons in each case : a. Investigation of size of bacterial cells b. Evaluation of impact of CO2 on the environment c. Diversity of microorganisms in the fields of Kohat University d. Investigation of new compounds in a bacterial culture e. Application of a strain of bacteria you isolated from the soil as PGPR

Briefly explain this statement -"Use of Laboratory Animals in Pharmaceutical Research " Please answer at your own words.

Antibiotic resistant bacteria have become a major concern for many public health officials. Widespread use of antibiotics has created an evolutionary pressure on infectious bacteria to develop immunity to these medications. The result is an increase in antibiotic resistant microbes, particularly in settings where antibiotics are commonly used, such as hospitals. One strategy public health officials have devised to counteract these infectious microbes is "antibiotic cycling” where specific antibiotics are withdrawn from the market for a period of several years, then reintroduced as another antibiotic is withdrawn. How would this strategy help limit antibiotic resistance? A. It is impossible for a bacterium to maintain resistance to two antibiotics at once B. When a given antibiotic is not in use, it is an evolutionary disadvantage to carry the unneeded gene C. If a specific antibiotic is removed from the market it is possible to substitute with a related antibiotic such as…