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Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 1, Problem 15RQ
Which of the following statements about nutrients is true?
- All classes of nutrients are essential to human survival.
- Because the body cannot store any micronutrients, they need to be consumed nearly every day.
- Carbohydrates, lipids, and proteins are micronutrients.
- Macronutrients are vitamins and minerals.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
Anatomy & Physiology
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Ch. 1 - Metabolism can be defined as the ________....Ch. 1 - Adenosine triphosphate (ATP) is an important...Ch. 1 - Cancer cells can be characterized as generic cells...Ch. 1 - Humans have the most urgent need for a continuous...Ch. 1 - Which of the following statements about nutrients...Ch. 1 - C.J. is stuck in her car during a bitterly cold...Ch. 1 - After you eat lunch, nerve cells in your stomach...Ch. 1 - Stimulation of the heat-loss center causes...Ch. 1 - Which of the following is an example of a normal...Ch. 1 - What is the position of the body when it is in the...Ch. 1 - To make a banana split, you halve a banana into...Ch. 1 - The lumbar region is ________. inferior to the...Ch. 1 - The heart is within the ________. cranial cavity...Ch. 1 - In 1901, Wilhelm Rontgen was the first person to...Ch. 1 - Which of the following imaging techniques would be...Ch. 1 - Which of the following imaging studies can be used...Ch. 1 - What are two major disadvantages of MRI scans?...Ch. 1 - Name at least three reasons to study anatomy and...Ch. 1 - For whom would an appreciation of the structural...Ch. 1 - Name the six levels of organization of the human...Ch. 1 - The female ovaries and the male testes are a part...Ch. 1 - Explain why the smell of smoke when you are...Ch. 1 - Identify three different ways that growth can...Ch. 1 - When you open a bottle of sparkling water, the...Ch. 1 - On his midsummer trek through the desert, Josh ran...Ch. 1 - Identify the four components of a negative...Ch. 1 - What regulatory processes would your body use if...Ch. 1 - In which direction would an MRI scanner move to...Ch. 1 - If a bullet were to penetrate a lung, which three...Ch. 1 - Which medical imaging technique is most dangerous...Ch. 1 - Explain why ultrasound imaging is the technique of...
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