You have the following DNA coding sequence of a wild-type allele: 5’-ATG TTC CAG CTA GAT GAT ATG CTG GTA ATT GGG GAA CGC GCG CGG TAA-3’ 1. For the second, third, fourth, and fifth codons, write all possible anticodon sequences (left-to-right, 5’-3’), including anticodons with wobble and inosine.
You have the following DNA coding sequence of a wild-type allele:
5’-ATG TTC CAG CTA GAT GAT ATG CTG GTA ATT GGG GAA CGC GCG CGG TAA-3’
1. For the second, third, fourth, and fifth codons, write all possible anticodon sequences (left-to-right, 5’-3’), including anticodons with wobble and inosine.
2. Write the amino acid sequence of the wild-type allele (three letter or single-letter amino acid abbreviation ok).
3. For each of the following mutations:
A. State whether the mutation is missense, nonsense, frameshift, or silent. B. Write the codon change that occurs for the missense, nonsense, and silent mutations (ex. GAA GAT).
C. For frameshift mutations, write out the entire mutant sequence with each codon clearly indicated (if the frameshift creates a new stop codon, end the sequence at the new stop).
D. Write the amino acid sequence of the mutants. Mutant 1: transition at
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