You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and menory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the phosphodiesterase enzyme inactive.
You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and menory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activated transcription of the gene Brainy. Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the phosphodiesterase enzyme inactive.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Transcribed Image Text:QUESTION 4
You are interested in how CAMP-dependent protein kinase A (PKA) functions to affect learning and memory, and
you decide to study its function in the brain. It is known that, in the cells you are studying, PKA is an effecter protein
of a GPCR signaling pathway that stimulates adenylyl cyclase. It is also known that activated PKA phosphorylates
the transcriptional regulator called Nerd that then activated transcription of the gene Brainy.
Explain the effect of mutation in the gene that encodes CAMP phosphodiesterase that makes the
phosphodiesterase enzyme inactive.
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