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You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.

You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.

Phlebotomy Essentials
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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FOR ACADEMIC PURPOSES ONLY - NOT FOR CLINICAL USE Test Details Gene Genotype Phenotype Alleles Tested CYP2C19 *2/*7 Poor Metabolizer *2, *3, *4, *48, *5, *6, *7, *8, *9, *17 CYP2D6 *1/4 Intermediate Metabolizer *2, *3, *4, *4M, "6, *7, *8, *9, *10, *12, *14A, *148, *17, *29, *35, *41 CYP3AS *3/*3 Poor Metabolizer *1D, *2, *3, *38, *3C, "6, *7, "8, *9 CYP3A4 *1/*1 Normal Metabolizer *18, *2, *3, *12, *17, *22 VKORCI -1639G>A G/A Intermediate Warfarin Sensitivity -1639G>A *2, *3 *2, *3, *4, *5, "6, *11 CYP4F2 *1/3 Decreased Function CYP2C9 *1/*1 Normal Metabolizer CYP2B6 *1/*1 Normal Metabolizer *6, *9 Normal Metabolizer - Higher Inducibility CYPIA2 *1F/"1F *1C, *1D, *1F, *1K, *1L, *1V, *1W SLCOIB1 521T>CT/T Normal Function 521T>C, 388A>G CFTR F508del/RS53X Negative Numerous DPYD *1/*1 Normal Metabolizer Numerous ТРМТ *1/*3A *1/1 Intermediate Metabolizer Normal Metabolizer *2, *3A, *38, *3C, *4 *2, *3, *4, *5, "6, *7, *8, *9 NUDT15 UGTIAI *1/*36 Normal Metabolizer *6, *27, *28, *36, *37, *60, "80 G6PD Bangkok or Bangkok/ Bangkok Deficient with CNSHA Numerous Additional Test Results (added to this original report) HLA-A*31:01 negative/negative Negative HLA-B'15:02 negative/negative Negative HLA-B'57:01 negative/negative Negative HLA-B'58.01 negative/negative Negative You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.
Transcribed Image Text:FOR ACADEMIC PURPOSES ONLY - NOT FOR CLINICAL USE Test Details Gene Genotype Phenotype Alleles Tested CYP2C19 *2/*7 Poor Metabolizer *2, *3, *4, *48, *5, *6, *7, *8, *9, *17 CYP2D6 *1/4 Intermediate Metabolizer *2, *3, *4, *4M, "6, *7, *8, *9, *10, *12, *14A, *148, *17, *29, *35, *41 CYP3AS *3/*3 Poor Metabolizer *1D, *2, *3, *38, *3C, "6, *7, "8, *9 CYP3A4 *1/*1 Normal Metabolizer *18, *2, *3, *12, *17, *22 VKORCI -1639G>A G/A Intermediate Warfarin Sensitivity -1639G>A *2, *3 *2, *3, *4, *5, "6, *11 CYP4F2 *1/3 Decreased Function CYP2C9 *1/*1 Normal Metabolizer CYP2B6 *1/*1 Normal Metabolizer *6, *9 Normal Metabolizer - Higher Inducibility CYPIA2 *1F/"1F *1C, *1D, *1F, *1K, *1L, *1V, *1W SLCOIB1 521T>CT/T Normal Function 521T>C, 388A>G CFTR F508del/RS53X Negative Numerous DPYD *1/*1 Normal Metabolizer Numerous ТРМТ *1/*3A *1/1 Intermediate Metabolizer Normal Metabolizer *2, *3A, *38, *3C, *4 *2, *3, *4, *5, "6, *7, *8, *9 NUDT15 UGTIAI *1/*36 Normal Metabolizer *6, *27, *28, *36, *37, *60, "80 G6PD Bangkok or Bangkok/ Bangkok Deficient with CNSHA Numerous Additional Test Results (added to this original report) HLA-A*31:01 negative/negative Negative HLA-B'15:02 negative/negative Negative HLA-B'57:01 negative/negative Negative HLA-B'58.01 negative/negative Negative You are head of a pharmaceutical R&D firm. Research has brought to you two drugs for the treatment of a disease. The major difference between the drugs is that one is significantly metabolized by two CYP P450 enzymes while the other is metabolized by only one CYP enzyme. Based on this data decide which drug to take to clinical trials (a $100,000,000 decision) and defend your choice. List three questions you might ask your researchers. Explain why they are important criteria for making a decision.
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