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You are given the following reactions to complete in lab. However, you recognize an issue with the reaction. 1. Determine why the reactions will not work or why the reactions will give a poor yield? 2. How can you resolve the issues and run the reactions to obtain a better yield? Fix the reactions by redrawing each reaction with the solution (corrected starting materials/reagents/products/etc.). Br NaBr DMSO NaOMe DMSO ta

You are given the following reactions to complete in lab. However, you recognize an issue with the reaction. 1. Determine why the reactions will not work or why the reactions will give a poor yield? 2. How can you resolve the issues and run the reactions to obtain a better yield? Fix the reactions by redrawing each reaction with the solution (corrected starting materials/reagents/products/etc.). Br NaBr DMSO NaOMe DMSO ta

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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can someone help me I figured the Br would be left and I would go with Na and then the bottom reactant would give a double bond. The second reaction I am a little lost on as well. 

**Title**: Understanding Reaction Issues and Optimization in Organic Synthesis **Introduction**: In this exercise, you are tasked with identifying and resolving issues within a set of given chemical reactions. This will enhance your understanding of reaction mechanisms and help you optimize conditions for better yield. --- **Objective**: 1. Determine why these reactions may not proceed as intended or why they might yield a poor output. 2. Propose solutions to improve the yield by correcting materials, reagents, or reaction conditions. --- **Reaction Analysis**: 1. **Reaction 1**: - **Reaction Scheme**: - Starting Material: A long alkyl chain. - Reagent: Sodium bromide (NaBr) in Dimethyl sulfoxide (DMSO). - Intended Product: Another long alkyl chain structure. **Issues to Consider**: - The choice of NaBr as a reagent may not favor the desired substitution or elimination. - DMSO is a polar aprotic solvent, suitable for SN2 reactions, but side reactions can occur. 2. **Reaction 2**: - **Reaction Scheme**: - Starting Material: A brominated aromatic compound. - Reagent: Sodium methoxide (NaOMe) in DMSO. - Intended Product: A methoxy-substituted aromatic compound. **Issues to Consider**: - The use of NaOMe could lead to competing elimination reactions. - The presence of a strong base in DMSO can favor side reactions over substitution. --- **Approach to Solutions**: - **Optimizing Reaction Conditions**: - Evaluate if the choice of reagents is suitable for the desired transformation. - Consider solvent effects—alternative solvents might improve the reaction selectivity and yield. - **Modification of Reagents or Conditions**: - Substitute NaBr or NaOMe with counterparts that might give better selectivity or compatibility. - Adjust the temperature or concentration to favor the desired reaction pathway. --- **Illustration (Graph/Diagram Explanation)**: - The diagrams illustrate the structural transformation intended by the reactions, with clear depiction of reactants and intended products. Attention should be given to the alignment of functional groups and potential sites for unwanted reactions. --- **Conclusion**: The analysis and modification of these reactions underscore the importance of strategic selection of reagents and conditions in organic synthesis. By understanding potential pitfalls and making precise modifications
Transcribed Image Text:**Title**: Understanding Reaction Issues and Optimization in Organic Synthesis **Introduction**: In this exercise, you are tasked with identifying and resolving issues within a set of given chemical reactions. This will enhance your understanding of reaction mechanisms and help you optimize conditions for better yield. --- **Objective**: 1. Determine why these reactions may not proceed as intended or why they might yield a poor output. 2. Propose solutions to improve the yield by correcting materials, reagents, or reaction conditions. --- **Reaction Analysis**: 1. **Reaction 1**: - **Reaction Scheme**: - Starting Material: A long alkyl chain. - Reagent: Sodium bromide (NaBr) in Dimethyl sulfoxide (DMSO). - Intended Product: Another long alkyl chain structure. **Issues to Consider**: - The choice of NaBr as a reagent may not favor the desired substitution or elimination. - DMSO is a polar aprotic solvent, suitable for SN2 reactions, but side reactions can occur. 2. **Reaction 2**: - **Reaction Scheme**: - Starting Material: A brominated aromatic compound. - Reagent: Sodium methoxide (NaOMe) in DMSO. - Intended Product: A methoxy-substituted aromatic compound. **Issues to Consider**: - The use of NaOMe could lead to competing elimination reactions. - The presence of a strong base in DMSO can favor side reactions over substitution. --- **Approach to Solutions**: - **Optimizing Reaction Conditions**: - Evaluate if the choice of reagents is suitable for the desired transformation. - Consider solvent effects—alternative solvents might improve the reaction selectivity and yield. - **Modification of Reagents or Conditions**: - Substitute NaBr or NaOMe with counterparts that might give better selectivity or compatibility. - Adjust the temperature or concentration to favor the desired reaction pathway. --- **Illustration (Graph/Diagram Explanation)**: - The diagrams illustrate the structural transformation intended by the reactions, with clear depiction of reactants and intended products. Attention should be given to the alignment of functional groups and potential sites for unwanted reactions. --- **Conclusion**: The analysis and modification of these reactions underscore the importance of strategic selection of reagents and conditions in organic synthesis. By understanding potential pitfalls and making precise modifications
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