Ye are helping clinicians to diagnose a patient with a rare liver condition. After some preliminary analysis, you suspect that the enzyme encoded by gene PHGDH is not been produced. You confirm this by looking for the protein on a protein gel. Now you want to see if the gene is expressed at all. You get the results on the image below, where the line labeled with a means a normal patient and - represents the sick patient. After genetic analysis of the gene sequence of the sick patient, you observed that the sequence looks identical to that of a non-sick patient (control). You suspect that histone acetylation may be defective. Based on the data you have gathered so far, what would you expect to see on a histone acetylation analysis of histone tails in the vicinity of the PHGDH gene promoter/enhancer regions? PHGDH mRNA Liver + 0000 - High levels of acetylation at the PHGDH promoter/enhancer region No difference, since acetylation has nothing to do with gene expression High levels of acetylation at the PHGDH protein coding region region O Low levels of acetylation at the PHGDH promoter/enhancer region
Ye are helping clinicians to diagnose a patient with a rare liver condition. After some preliminary analysis, you suspect that the enzyme encoded by gene PHGDH is not been produced. You confirm this by looking for the protein on a protein gel. Now you want to see if the gene is expressed at all. You get the results on the image below, where the line labeled with a means a normal patient and - represents the sick patient. After genetic analysis of the gene sequence of the sick patient, you observed that the sequence looks identical to that of a non-sick patient (control). You suspect that histone acetylation may be defective. Based on the data you have gathered so far, what would you expect to see on a histone acetylation analysis of histone tails in the vicinity of the PHGDH gene promoter/enhancer regions? PHGDH mRNA Liver + 0000 - High levels of acetylation at the PHGDH promoter/enhancer region No difference, since acetylation has nothing to do with gene expression High levels of acetylation at the PHGDH protein coding region region O Low levels of acetylation at the PHGDH promoter/enhancer region
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Ye are helping clinicians to diagnose a patient with a rare liver condition. After
some preliminary analysis, you suspect that the enzyme encoded by gene PHGDH
is not been produced. You confirm this by looking for the protein on a protein gel.
Now you want to see if the gene is expressed at all. You get the results on the
image below, where the line labeled with a means a normal patient and -
represents the sick patient. After genetic analysis of the gene sequence of the sick
patient, you observed that the sequence looks identical to that of a non-sick
patient (control). You suspect that histone acetylation may be defective. Based on
the data you have gathered so far, what would you expect to see on a histone
acetylation analysis of histone tails in the vicinity of the PHGDH gene
promoter/enhancer regions?
PHGDH mRNA
CO
Liver
+
High levels of acetylation at the PHGDH promoter/enhancer region
No difference, since acetylation has nothing to do with gene expression
High levels of acetylation at the PHGDH protein coding region region
Low levels of acetylation at the PHGDH promoter/enhancer region
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