X linked recessive mutations in the dystrophin gene cause muscular dystrophy. The gene is enormous, over 1 million base pairs. Because it is that large, the gene can not be readily inserted into a virus for gene therapy. What other technique that we have discussed could you use to do gene therapy on this condition?

X linked recessive mutations in the dystrophin gene cause muscular dystrophy. The gene is enormous, over 1 million base pairs. Because it is that large, the gene can not be readily inserted into a virus for gene therapy. What other technique that we have discussed could you use to do gene therapy on this condition?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 14QP

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Genes with highly similar sequence are often located adjacent one another in the genome. Gene duplication commonly arises from errors in replication. When the organization of such adjacent genes is in an inverted orientation, this can reduce the expression of other genes that have similar sequence and are located on other chromosomes. Explain the mechanism of how this generally occurs. i need a detailed explanation, please. I need to know what the mechanism is. How it happens and why. Please. Thanks
Researchers have identified a gene in humans that (when mutated) causes tremors and unstable walking due to neurological problems. This disorder is inherited in an autosomal recessive manner, and the mutant allele isknown to result from a loss-of-function mutation. The same gene hasbeen found in mice, although a mutant mouse version has not beendiscovered. To develop an effective drug therapy to treat this disorderin humans, it would be experimentally useful to have a mouse model.In other words, it would be desirable to develop a strain of mice thatcarry the mutant allele in the homozygous condition. How would youdevelop such a strain?
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Look at Figure 17-22 and state which bands are missing in the cri du chat deletion.
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