Write down the flow chart of Hand molding process for the manufacturing of suppositories? Please answer at your own words.
Answer -
Suppositories -
Suppositories are generally made from solid ingredients and drugs which are measured by weight. When they are mixed, melted, and poured into suppository mold cavities, they occupy a volume – the volume of the mold cavity. .If the drug has the same density as the base, it will displace an equivalent weight of the base.
This is the oldest and the simplest method of preparing suppositories. The manipulation requires considerable skill, yet avoids the complications of heat and mold preparation. with medicament is rolled with the hand & the desired shape is given
Take the prescribed quantity of the medicinal substances and a sufficient quantity of theobroma oil/suppository base. The correct amount of grated theobroma oil then is added, and a mass resembling a pill is made by thoroughly incorporating the ingredients with a pestle.
When the mass has become plastic under the vigorous kneading of the pestle, it quickly is loosened from the mortar with a spatula, and then transferred with the spatula to a piece of filter paper that is kept between the mass and the hands during the kneading and rolling procedure. By quick, rotary movements of the hands, the mass is rolled to a ball, which immediately is placed on a pill tile.
The kneaded mass is rolled between fingers into rod-shaped units. The rods are cut into pieces and then one end is pointed with the help of spatula
The suppository “pipe” or cylinder tends to crack or hollow in the center, especially when the mass is insufficiently kneaded and softened.
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