With which kind of antibiotic (static or cidal) would you expect the MIC and MBC to be about the same concentration and to be vastly different concentrations
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With which kind of antibiotic (static or cidal) would you expect the MIC and MBC to be about the same concentration and to be vastly different concentrations
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- The reason why most antibiotics as oral suspension dosage forms are commercially available as dry powders, to be reconstituted with water just prior to dispensing, is:Below, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?If you have 4 compounds and you test them for antimicrobial activity using a disk diffusion assay and one is very active, one is moderately active, one is slightly active and one is not active at all, draw the disk, the zone of inhibition that you would see and a pretend numerical value to indicate the size of the zone in mm, give each one a number 1 – 4 and rank them from most effective to least effective as an antimicrobial.
- isolating a suspected agent in a sick individual that is absent in a healthy individual is sufficient to establish that the agent causes the disease? True or FalseThe Kirby-Bauer test is useful for determining Multiple Choice the minimum inhibitory concentration of an antibiotic. whether side effects will result from use of an antibiotic. the sensitivity of a microorganism to an antibiotic the right dose of an antibiotic for treatment of infectionYour labmate forgot to use CBB-R250 in the process. Which of the following would most likely be the resulting gel?
- A bacterium can protect itself against antibiotics in different ways. Describe 4 fundamentally differentmechanisms of antibiotic resistance. Discuss whether there are any basicdifferences or similarities between these 4 mechanisms and, if so, describe them.This is a walk-through of Minimum Inhibitory Concentration, MIC: This tray has 8 rows, 4 for Staphylococcus aureus (SA) and 4 for Methicillin-Resistant S. aureus (MRSA). Each row has 12 compartments, or wells. The wells have different concentrations (ug/ml) of the antibiotic Oxacillin in them. From Left to Right, the concentration of Oxacillin is going down acillin concentration, pg/ml 64 32 16 8 4 2 1 0.5 0.25 0.13 0.06 0 SA dn The same amount of S. aureus broth culture is added to each well and the tray is incubated. A color change shows that S. aureus grew in a given well. MRSA What is the lowest concentration at which SA is inhibited (does not grow)? 64mg/ml What is the lowest concentration at which MRSA is inhibited? What is the MIC for Oxacillin vs SA? What is the MIC for Oxacillin vs MRSA? - Notes Comments 33°Fdiameter AM=47MM TE= 27 MM both left hand side is ampicillin and right hand side is tetracycline With reference to the table below, determine the antibiotic susceptibilities of different antibiotics against coli and S.aureus. S.aureus Antimicrobial agent Interpretive categories and zone diameter breakpoints, nearest whole mm sensitive Intermediate resistant Tetracycline >19 15-18 <14
- Broad-spectrum drugs target a wide variety of bacterial pathogens. Even when the broad-spectrum drug is capable of killing a target pathogen, it may not be the best treatment. Which statement best explains why a broad spectrum drug might be an undesirable treatment choice? Broad-spectrum antimicrobials are usually toxic to the host cells. Broad-spectrum antimicrobials only work if they are used shortly after the infection begins. Broad-spectrum antimicrobials may kill much of the normal microbiota. Broad-spectrum antimicrobials are not able to kill bacteria that are in their log phase of growth. Broad-spectrum antimicrobials may stimulate excess growth of the normal microbiota.Make a conceptual framework based on this concept (Antimicrobial Resistance).We have many antimicrobial drugs to treat bacterial infections, but very few for viruses. Why is it so difficult to treat viral infections? Hint: What would the targets for the drugs be?