The so-called hypervariable regions (HV1 and HV2) of the human mitochondrial genome are sometimes used in forensic analysis. They are two noncoding regions of the mitochondrial genome, each approximately 300 bp, that flank the origin of replication; the function of these DNA sequences is not well understood. However, these two regions of mtDNA show the most variation (SNPs and InDels) among different people. The DNA within HVI and HV2 accumulates mutations at ten times the rate of DNA sequences in the nuclear genome. a. Under what circumstances would human mtDNA be preferable over nuclear DNA for identifying individuals?

Q: People who carry a theoretical genetic disorder (called B-disease) can be identified from a 2kb DNA…

A: Molecular mapping is used to find the location of gene on the chromosome and also the distance…

Q: Recombination signal sequences are conserved heptamer and nonamer sequences that flank the V, J, and…

A: Introduction: RAG 1 & 2 are the recombination activating genes that encode a portion of a…

Q: A 210-bp sequence within the CFTR gene on human chromosome 7 is shown below. The three bold…

A: A primer is a short DNA sequence that serves as a starting point for DNA synthesis in a polymerase…

Q: The DNA of a skin sell and a muscle cell are identical. But the skin cell may contain the proteins…

A: DNA (Deoxyribonucleic acid) is a double helical structure present in nucleus of a cell and contains…

Q: The Borrelia hermsii spirochete causes a relapsing fever, characterized by multiple periods of high…

A: Borrelia hermsii are spirochete bacteria that have a thin long and spiral shape and move with the…

Q: Trinucleotide repeat expansions (TNREs) are associated with severaldifferent human inherited…

A: The trinucleotide repeat expansion is also called triplet repeat expansion. It is a DNA mutation and…

Q: People with a commonly occurring, wild type allele of PTC with two adjacent thymines at a particular…

A: Part a.) :-ans.The presence of two adjacent thymines at a specific site in the PTC coding sequence…

Q: ckle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal…

A:

Q: Assume that a DNA sequencing reaction is carried out, except that the four different…

A: Ans: DNA sequencing: It is the process of knowing the sequence of the DNA. The DNA sequencing is of…

Q: The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal…

A: A person with agammaglobulinemia has extremely low levels of the immune system's defense proteins,…

Q: The entire genome of the yeast Saccharomyces cerevisiae has been sequenced. This sequencing has led…

A: The entire genome of the yeast has been sequenced and open reading frames (sequences with…

Q: You learned in Problem 21 in Chapter 7 that theneurodegenerative disease ALS can be caused by…

A: Amyotrophic lateral sclerosis (ALS) is a paralyzing neurodegenerative disease which is usually fatal…

Q: The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal…

A: A person with agammaglobulinemia has extremely low levels of the immune system's defense proteins,…

Q: The DNA located inside of mitochondria exhibits approximately ten times the mutation rate seen in…

A: Mitochondria is a double membrane-bound cell organelle that is used to generate ATP molecules…

Q: People who carry a theoretical genetic disorder (called B-disease) can be identified from a 2kb DNA…

A: A genetic disorder is an inherited abnormal condition concerning the genetic material i.e. DNA.…

Q: Suppose that a nearly perfect 20-base-pair inverted repeat is observed in a DNA sequence. Provide…

A: The copies of the DNA sequences that are organized in opposing orientation are called “inverted…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.