Why is this statement false? Without the renal medullar osmotic gradient, you would not be able to raise the concentration of urine above 1200 mOsm
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- Which of the following does not contribute to the high salt concentration in the interstitial fluid of the kidney medulla? (a) active transport of sodium from the upper part of the ascending limb (b) diffusion of salt from the ascending limb of the loop of Henle (c) reabsorption of salt from various regions of Bowmans capsule (d) counterflow of fluid through the two limbs of the loop of Henle (e) diffusion of urea out of the collecting ductWhich of the following does not contribute to the process of filtration? (a) active transport by epithelial cells lining renal tubules (b) large surface area for filtration (c) low permeability of glomerular capillaries (d) high hydrostatic blood pressure in glomerular capillaries (e) podocytesPressure in the renal artery is 100 mm Hg and the pressure in the renal vein is 50 mm Hg. The resistance of the afferent arteriole equals 0.5 mm Hg•min/L and the resistance of the efferent arteriole equals 0.5 mm Hg•min/L. What is the pressure in the glomerulus?
- Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.One model of the glomerular membrane is a microporous membrane in which right cylindrical pores penetrate all the way through the membrane. Assume that the pores have a length of 50 nm and a radius of 3.5 nm. The viscosity of plasma is 0.002 Pa s. The average hydrostatic pressure in the glomerulus is 60 mm Hg, hydrostatic pressure in Bowman's space is 20 mm Hg and the average oncotic pressure of glomerular capillary blood is 28 mm Hg. A. Calculate the flow through a single pore assuming laminar flow (use the Poiseuille flow equation) B. How many pores would there have to be to produce a normal GFR? C. If the total aggregate area of the kidneys for filtration is 1.5 m2, what is the density of the pores (number of pores per unit area)? D. What fraction of the area is present as pores?Even though mutations of aquaporin-3 and aquaporin-4 in the collecting duct have not been described in the literature, if mutationsoccurred that resulted in a reduced number of these aquaporins in thecells of the collecting ducts, how would urine volume and concentrationbe affected? Would ADH be an effective treatment?
- Glomerular filtration is affected by forces that oppose and promote filtration. What are these forces and explain the theory behind net filtration pressure?A patient comes to your medical practice with complaints of low urine output (not peeing). You use inulin to calculate the glomerular filtration rate (GFR) using the following information: Plasma level (P – constant over 24 hours): 10 mg/mL inulin. Urine sample (U): 144 mg inulin/mL urine. Urine formation (V): 10 mL/min. Using the fromula GFR=V ✕ U/P, you calculate a GFR of ... A) 144mL/min.. B) 14400 mL/min. C) 144 min./mL. D) 144 g mannitol/min.What is an example of a diagram that explains the core concept of flow down gradients in the urinary system/kidneys?
- Is this following statement correct? In the kidney, vasoconstriction of the afferent arteriole increases glomerular filtration rate, because hydrostatic pressure in the glomerular capillaries increases (much like putting your thumb over the end of a garden hose increases the pressure and causes the water to exit the hose with greater velocity and travel a greater distance).The renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations. For the three lines shown (labeled A-C) identify which line represents filtration, which line represents secretion, and which line represents excretion Explain how you determined this.What are the two intrinsic mechanisms that provide auto regulation of glomerular filtrate? Explain any one of these.