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Q: labeled secondary
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Why is IgM particularly effective at cross-linking antigens?
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- Why is it better to use an unlabeled primary antibody and a labeled secondary over just labeling the primary antibody?What is Natural antibodies?Which antibody type description among A- D is falsely characterized? A) O IgA: form dimers; prevent adherence of pathogens to mucosal surfaces 1f1 B) O IgG: circulating antibody with multiple functions; formed in high numbers in secondary antibody response C) O IgM: forms multimers whose function is agglutination of infectious microbes D) O IgE, IgD: carry out their function while bound to the surfaces of specific cell types E) O None are false, A-D are all correct
- How and why do B cells undergo a class switch from producing IgM antibodies to any of the other Ig isotypes?What is the point to labeling a secondary antibody with a marker that can be visualized instead of just labeling the primary antibody?Why specifically is IgM produced upon the primary immune response while IgG is produced upon the secondary immune response?
- A person with type A+ blood gets a transfusion with type O- blood. What is most likely to happen to the recipient? A) The recipient's blood will agglutinate (clump) due to the presence of natural antibodies in the recipient's blood. B) Nothing because the donor's blood is compatible with the recipient's blood. C) The recipient's blood will agglutinate (clump) due to the presence of natural antigens on the recipient's blood cells.What are chimeric antigen receptors, and how are they constructed?Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.