Which statements are true?The transition state is the highest free energy that a reaction reaches during its progress from reactants to products.Enzymes alter the free energy of the transition state but not its chemical nature.High affinity binding of substrate by enzymes alters the equilibrium between reactants (substrates) and products.High affinity binding of substrate by enzymes can impede reaching the transition state.Steric and electrostatic interactions between the enzyme and substrate usually disfavor the ground state of substrate and favor the formation of the transition state.If ∆G‡(catalyzed) is less positive than ∆G‡(uncatalyzed) then the enzyme is enhancing the rate of the reaction.Low affinity binding of substrate by the enzyme must always lead to a slower rate of reaction compared to the uncatalyzed rate.There is no barrier to substrate binding to an enzyme, only to the chemical step.

The enzymes are the biological catalysts that enhance the rate of a chemical reaction. The…

Answered: Which statements are true? The…

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

Related questions

Question

Which statements are true?

The transition state is the highest free energy that a reaction reaches during its progress from reactants to products.
Enzymes alter the free energy of the transition state but not its chemical nature.
High affinity binding of substrate by enzymes alters the equilibrium between reactants (substrates) and products.
High affinity binding of substrate by enzymes can impede reaching the transition state.
Steric and electrostatic interactions between the enzyme and substrate usually disfavor the ground state of substrate and favor the formation of the transition state.
If ∆G^‡(catalyzed) is less positive than ∆G^‡(uncatalyzed) then the enzyme is enhancing the rate of the reaction.
Low affinity binding of substrate by the enzyme must always lead to a slower rate of reaction compared to the uncatalyzed rate.
There is no barrier to substrate binding to an enzyme, only to the chemical step.