Which schematic below best represents the mechanism of DNA replication for a replication fork that is moving to the left (select one)? 5' 3'- 5' 3' A C 3' i in '5' 3' 5' 5' 3' 5' 3' B D 3' '5' 3' 5'

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**Question:**
Which schematic below best represents the mechanism of DNA replication for a replication fork that is moving to the left (select one)?

**Description of Schematics:**

- **Schematic A:**
  - The DNA double helix is unwound, with the replication fork opening towards the left.
  - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the left fork.
  - Lagging strand: The 5' to 3' direction arrow also points towards the fork, indicating discontinuous synthesis towards the same leftward direction.

- **Schematic B:**
  - The DNA double helix is unwound, with the replication fork opening towards the left.
  - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the right, away from the fork.
  - Lagging strand: The 5' to 3' direction arrows point away from the fork, suggesting movement to the right.

- **Schematic C:**
  - The DNA double helix is unwound, with the replication fork opening towards the left.
  - Leading strand: The 5' to 3' direction arrow points towards the fork, indicating continuous synthesis to the left.
  - Lagging strand: The 5' to 3' direction arrow points away from the fork, suggesting movement to the right.

- **Schematic D:**
  - The DNA double helix is unwound, with the replication fork opening towards the right.
  - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the fork.
  - Lagging strand: The 5' to 3' direction arrow indicates discontinuous synthesis towards the fork.

**Explanation:**
In DNA replication, the leading strand is synthesized continuously in the direction of the replication fork's movement (5' to 3'), while the lagging strand is synthesized discontinuously in segments known as Okazaki fragments, also in the 5' to 3' direction but away from the fork. For a replication fork moving to the left, the correct schematic must show the leading strand being synthesized continuously to the left, and the lagging strand being synthesized in fragments also towards the left.

**Correct Answer:**
Schematic A.
Transcribed Image Text:**Question:** Which schematic below best represents the mechanism of DNA replication for a replication fork that is moving to the left (select one)? **Description of Schematics:** - **Schematic A:** - The DNA double helix is unwound, with the replication fork opening towards the left. - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the left fork. - Lagging strand: The 5' to 3' direction arrow also points towards the fork, indicating discontinuous synthesis towards the same leftward direction. - **Schematic B:** - The DNA double helix is unwound, with the replication fork opening towards the left. - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the right, away from the fork. - Lagging strand: The 5' to 3' direction arrows point away from the fork, suggesting movement to the right. - **Schematic C:** - The DNA double helix is unwound, with the replication fork opening towards the left. - Leading strand: The 5' to 3' direction arrow points towards the fork, indicating continuous synthesis to the left. - Lagging strand: The 5' to 3' direction arrow points away from the fork, suggesting movement to the right. - **Schematic D:** - The DNA double helix is unwound, with the replication fork opening towards the right. - Leading strand: The 5' to 3' direction arrow indicates continuous synthesis towards the fork. - Lagging strand: The 5' to 3' direction arrow indicates discontinuous synthesis towards the fork. **Explanation:** In DNA replication, the leading strand is synthesized continuously in the direction of the replication fork's movement (5' to 3'), while the lagging strand is synthesized discontinuously in segments known as Okazaki fragments, also in the 5' to 3' direction but away from the fork. For a replication fork moving to the left, the correct schematic must show the leading strand being synthesized continuously to the left, and the lagging strand being synthesized in fragments also towards the left. **Correct Answer:** Schematic A.
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