Which one of the following statements about arene oxides is FALSE? O The NIH shift is what makes arene oxides carcinogenic. O Ring opening of an arene oxide can afford an addition product and/or a rearranged product. O Large polycyclic aromatic hydrocarbons such as benzo[a]pyrene are especially susceptible to arene oxide formation. O The NIH shift mechanism was discovered at the National Institutes of Health. O Cytochrome P450 is the powerful biological oxidant that epoxides an arene to give an arene oxide.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![Which one of the following statements about arene oxides is FALSE?
O The NIH shift is what makes arene oxides carcinogenic.
O Ring opening of an arene oxide can afford an addition product and/or a rearranged
product.
O Large polycyclic aromatic hydrocarbons such as benzo[a]pyrene are especially
susceptible to arene oxide formation.
The NIH shift mechanism was discovered at the National Institutes of Health.
O Cytochrome P450 is the powerful biological oxidant that epoxides an arene to give
an arene oxide.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff1d6ac3e-bb28-4ddf-88c4-42008460867a%2Fbe70e700-b3d5-42ef-8997-a047357854a8%2Fisizhll_processed.png&w=3840&q=75)
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